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2024
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Bidirectional Effect of Long-term Delta-9-Tetrahydrocannabinol treatment on mTOR activity and Metabolome. https://pubs.acs.org/doi/10.1021/acsptsci.4c00002
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What this article reports is; that in a mouse model, long-term delta-9-THC "first increases the level of energy and synaptic protein production in the brain, followed by a reduction in mTOR activity and metabolic processes in the periphery. Our study suggests that a dual effect on mTOR activity and the metabolome could be the basis for an effective antiaging and pro-cognitive medication."
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- CANNABIS INSTEAD OF POLYPHARMACY? Could cannabis be the safer alternative prescribers and patients are looking for? https://www.projectcbd.org/medicine/cannabis-instead-polypharmacy?utm_source=Project%20CBD%20Mailing%20List&utm_campaign=16009440cf-EMAIL_CAMPAIGN_2019_11_18_03_47&utm_medium=email&utm_term=0_ea5031784e-16009440cf-11562609
- Condition Report: Dementia: https://canneconomy.com/report/condition-report-dementia/
- DIET & THE ENDOCANNABINOID SYSTEM: https://www.projectcbd.org/food-for-thought-diet-cannabis-and-the-endocannabinoid-system?utm_source=Project+CBD+Mailing+List&utm_campaign=e12620d33f-EMAIL_CAMPAIGN_2019_10_22_07_28&utm_medium=email&utm_term=0_ea5031784e-e12620d33f-6830217
- How Should Hospices Handle Legalized Medical Marijuana? (news–2016 p. 178) https://marlin-prod.literatumonline.com/pb-assets/Lancet/lancet/TL_USA_Posts.pdf
- Want to Know How Marijuana Can Reverse Aging? (news–2018) https://thefreshtoast.com/cannabis/marijuana-can-it-reverse-aging-and-other-signs-of-oxidative-stress/
- Aging & Medical Marijuana. (USA) (booklet – undated) https://www.safeaccessnow.org/aging
- 2019
- Marijuana use is growing among seniors. What does it mean when our largest
demographic lights up? (news – 2019)
https://www.thegrowthop.com/cannabis-news/cannabis-use-seniors-canada-rise-what-happens-when-they-light-up - Can cannabis reverse the aging process in humans? (news – 2019)
https://www.thegrowthop.com/cannabis-health/could-cannabis-can-reverse-the-aging-process-in-humans - Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype. (USA, full, 2019) https://www.frontiersin.org/articles/10.3389/fnmol.2019.00142/full
- FAAH genotype, CRFR1 genotype, and cortisol interact to predict anxiety in an aging, rural Hispanic population: A Project FRONTIER study. (USA, full, 2019) https://www.sciencedirect.com/science/article/pii/S2352289518300997?via%3Dihub
- Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis. (Germany, full, 2019) https://www.frontiersin.org/articles/10.3389/fimmu.2018.02671/full
- Sex differences in distribution of cannabinoid receptors (CB1 and CB2), S100A6 and CacyBP/SIP in human ageing hearts. (Poland, full, 2019) https://bsd.biomedcentral.com/articles/10.1186/s13293-018-0209-3
- A Review on Studies of Marijuana for Alzheimer's Disease - Focusing on CBD, THC. (Republic of Korea, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970569/
- Aging circadian rhythms and cannabinoids. (USA, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0197458019300867?via%3Dihub
- The Endocannabinoid System May Modulate Sleep Disorders In Aging. (Brazil, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31368874/
- Diet, endocannabinoids, and health. (USA, abstract, 2019) https://www.sciencedirect.com/science/article/pii/S027153171930572X?via%3Dihub
- Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations. (Italy, abstract, 2019) https://www.eurekaselect.com/172649/article
- Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. (USA, abstract, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548519/
- Liquid chromatography-mass spectrometry identification of serum biomarkers for nocturia in aged men. (Japan, abstract, 2019) https://link.springer.com/article/10.1007/s00345-019-02647-4
- β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice. (Mexico, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31663807/
- Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers. (USA, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0925492718302683
- Cannabis Exposure is Associated With a Lower Likelihood of Neurocognitive Impairment in People Living With HIV. (USA, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31809361/
- The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling. (China, abstract, 2019) https://link.springer.com/article/10.1007%2Fs12640-019-00141-8
- 2018
- Profiling plasma N-Acylethanolamine levels and their ratios as a biomarker of obesity and dysmetabolism. (Italy, full, 2018) https://www.sciencedirect.com/science/article/pii/S2212877818303934?via%3Dihub
- Vicious Circle Leads to Loss of Brain Cells in Old Age: THC May Help Reverse the
Process. (news/ abst – 2018) https://neurosciencenews.com/apoptosis-aging-9783/ - ‘Unique’ cannabis compound reverses brain aging in mice. (news – 2018)
https://www.dw.com/en/unique-cannabis-compound-reverses-brain-aging-in-mice/a-44401750 - Want To Know How Marijuana Can Reverse Aging? (news – 2018)
https://thefreshtoast.com/cannabis/want-to-know-how-marijuana-can-reverse-aging/ - How Marijuana Does More For Age-Related Osteoporosis Than Calcium (news–2018) https://thefreshtoast.com/cannabis/how-marijuana-does-more-for-age-related-osteoporosis-than-calcium/
- An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. (Italy, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/
- Cannabinoid 1 receptor signaling on GABAergic neurons influences astrocytes in the ageing brain. (Italy/ Germany, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095551/
- Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders. (China/ Russia/ USA/ Germany, full, 2018) https://www.nature.com/articles/s41380-018-0200-8
- Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. (Brazil, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120904/
- THC for age-related cognitive decline? (Israel, full, 2018) https://www.aging-us.com/article/101648/text
- Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290479/
- Endocannabinoids, exercise, pain, and a path to health with aging. (USA, full, 2018) https://www.researchgate.net/publication/328114934_Endocannabinoids_exercise_pain_and_a_path_to_health_with_aging
- Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells. (Spain/ UK, abstract, 2018) https://www.semanticscholar.org/paper/Effect-of-endocannabinoid-signalling-on-cell-fate%3A-Garc%C3%ADa-Arenc%C3%ADbia-Molina-Holgado/3afc0cb06c7e7d2f36054d0286d126e462b49f7f
- Dermatology-Related Uses of Medical Cannabis Promoted by Dispensaries in Canada, Europe, and the United States. (Canada, abstract, 2018) https://journals.sagepub.com/doi/abs/10.1177/1203475418808761?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=cmsa&
- Effects of Cannabidiol on Diabetes Outcomes and Chronic Cerebral Hypoperfusion Comorbidities in Middle-Aged Rats. (Brazil, abstract, 2018) https://link.springer.com/article/10.1007/s12640-018-9972-5
- 2017
- Undeniable Evidence: Cannabis, Alzheimer’s and Dementia (news–2017) https://unitedpatientsgroup.com/blog/2017/03/15/undeniable-evidence-cannabis-alzheimers-and-dementia/
- Science: Marijuana Can Reverse The Aging Process In Humans (news–2017) https://thefreshtoast.com/cannabis/heres-why-marijuana-reverses-the-aging-process/
- Marijuana May Boost, Rather Than Dull, the Elderly Brain (news–2017) https://www.scientificamerican.com/article/marijuana-may-boost-rather-than-dull-the-elderly-brain/
- All About Marijuana Outreach At Retirement Communities (news–2017)
https://thefreshtoast.com/news/retirement-communities-want-to-learn-more-about-marijuana/ - Seniors Buy Fewer Prescription Drugs In States That Have Legalized Marijuana (news–2017) https://thefreshtoast.com/cannabis/states-that-have-legalized-marijuana/
- Why Is Marijuana Use Among Seniors on the Rise? (news–2017) http://www.healthline.com/health-news/why-are-more-seniors-using-marijuana#5
- Marijuana: Can It Reverse Aging and Other Signs of Oxidative Stress? (news – 2017)
https://thefreshtoast.com/cannabis/marijuana-can-it-reverse-aging-and-other-signs-of-oxidative-stress/ - Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314369/
- Interplay Between n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids and the Endocannabinoid System in Brain Protection and Repair. (USA, full, 2017) https://link.springer.com/article/10.1007%2Fs11745-017-4292-8
- Reversal of age-related cognitive impairments in mice by an extremely low dose of tetrahydrocannabinol. (Israel, full, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0197458017303214
- Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model. (China, full, 2017) https://www.hindawi.com/journals/ecam/2017/4757520/
- Obesity is a concern for bone health with aging. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385856/
- MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2. (China, full, 2017) https://www.mdpi.com/1422-0067/20/16/3979/htm
- Modeling Neurodegenerative Disorders for Developing Cannabinoid-Based Neuroprotective Therapies. (Spain, full, 2017) https://books.google.com/books?hl=en&lr=&id=bSwUDgAAQBAJ&oi=fnd&pg=PA175&ots=2M37z6ehcF&sig=FRwGUkrfqwLhBf8sxV6CZVmjFik#v=onepage&q&f=false
- A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. (Germany/ Israel, click “drperlmutter” for download, 2017) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22A+chronic+low+dose+of+%CE%949-tetrahydrocannabinol+%28THC%29+restores+cognitive+function+in+old+mice%22&btnG
- Marijuana Use in the Elderly: Implications and Considerations. (USA, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/28595684/
- 2016
- Vaping weed is good for your skin (news–2016) http://metro.co.uk/2016/03/18/vaping-weed-is-good-for-your-skin-5759607/
- Marijuana May Boost Brain Performance (news–2016)
http://www.worldhealth.net/news/marijuana-may-boost-brain-performance/ - Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells (news–2016) https://www.sciencedaily.com/releases/2016/06/160629095609.htm
- Marijuana Use by Older Adults (news–2016) http://learnaboutmarijuanawa.org/factsheets/olderadults.htm
- Illegal Patient Profiles: Spending the Golden Years with Cannabis (news–2016) https://www.marijuanatimes.org/illegal-patient-profiles-spending-the-golden-years-with-cannabis/
- Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514994/
- CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction. (UK/ China, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783351/
- β-Caryophyllene promotes osteoblastic mineralization, and suppresses osteoclastogenesis and adipogenesis in mouse bone marrow cultures in vitro. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228512/
- Protective effects of trans-caryophyllene on maintaining osteoblast function. (USA, full, 2016) https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.1584
- Metabolomic-Driven Elucidation of Serum Disturbances Associated with Alzheimer's Disease and Mild Cognitive Impairment. (Spain, link to PDF, 2016) https://www.researchgate.net/publication/292388470_Metabolomic-Driven_Elucidation_of_Serum_Disturbances_Associated_with_Alzheimer's_Disease_and_Mild_Cognitive_Impairment
- Metabolomic-Driven Elucidation of Serum Disturbances Associated with Alzheimer's Disease and Mild Cognitive Impairment. (Spain, link to PDF, 2016) https://www.researchgate.net/publication/292388470_Metabolomic-Driven_Elucidation_of_Serum_Disturbances_Associated_with_Alzheimer's_Disease_and_Mild_Cognitive_Impairment
- Circulating levels of endocannabinoids and oxylipins altered by dietary lipids in older women are likely associated with previously identified gene targets. (USA, link to PDF, 2016) https://www.researchgate.net/publication/305630631_Circulating_levels_of_endocannabinoids_and_oxylipins_altered_by_dietary_lipids_in_older_women_are_likely_associated_with_previously_identified_gene_targets
- Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model. (Spain, link to PDF, 2016) https://www.researchgate.net/publication/306246526_Delineating_the_Efficacy_of_a_Cannabis-Based_Medicine_at_Advanced_Stages_of_Dementia_in_a_Murine_Model
- Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats. (Poland, abstract, 2016) https://www.semanticscholar.org/paper/Age-specific-influences-of-chronic-administration-Toczek-Baranowska-Kuczko/d3e2b54c36a417b6cec6463c7e32b9ece130e817
- Lack of hippocampal CB1 receptor desensitization by Δ9-tetrahydrocannabinol in aged mice and by low doses of JZL 184. (Germany, abstract, 2016) https://www.semanticscholar.org/paper/Lack-of-hippocampal-CB1-receptor-desensitization-by-Feliszek-B%C3%AEndila/179b0990b53e615aa8e47db1d11f0899172b249d
- Selective modulator of cannabinoid receptor type 2 reduces memory impairment and infarct size during cerebral hypoperfusion and vascular dementia. (India, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27586843/
- 2015
- Potential Therapeutical Contributions of the Endocannabinoid System towards Aging and Alzheimer's Disease. (France/ USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567222/
- Age-related changes in the endocannabinoid system in the mouse hippocampus. (Germany, abstract, 2015) https://www.sciencedirect.com/science/article/abs/pii/S0047637415300099
- Pro-inflammatory obesity in aged cannabinoid-2 receptor deficient mice. (Germany, abstract, 2015) https://www.nature.com/articles/ijo2015169
- 2014
- Cannabis in Anti Aging Skin Care is Smoking Hot (news–2014) https://www.truthinaging.com/review/cannabis-in-anti-aging-skin-care-is-smoking-hot
- Monterey County seniors finding pain relief in medical marijuana (news–2014) http://www.montereyherald.com/20140830/monterey-county-seniors-finding-pain-relief-in-medical-marijuana
- 4 Mind Blowing Ways Cannabis Can Help Your Brain (news–2014) https://www.medicaljane.com/2014/12/14/4-mind-blowing-ways-marijuana-can-help-your-brain/
- 2012
- Israel pushing ahead in medical marijuana industry (news–2012) http://www.usatoday.com/story/news/world/2012/11/03/israel-medical-marijuana-drugs/1678641/
- How Cannabinoids May Slow Brain Aging (news–2012)
http://healthland.time.com/2012/10/29/how-cannabinoids-may-slow-brain-aging/ - 2011
- Endocannabinoid Signaling In Dietary Restriction And Lifespan Extension (news–2011) http://www.medicalnewstoday.com/releases/225007.php
- Cannabinoid-1 Receptor Protects The Brain From Aging (news–2011)
http://www.medicalnewstoday.com/releases/230948.php - Bodyguard for the Brain: Researchers Identify Mechanism That Seems to Protect Brain from Aging (news–2011)
http://www.sciencedaily.com/releases/2011/07/110712093856.htm - 125 Year Old Woman Claimed Smoking Cannabis Everyday Was Her Secret to Long Life (news–2011) http://www.hanf-info.ch/info/en/125-Year-Old-Woman-Claimed-Smoking.html
- 2010
- Pot for Grandma? Middle-Aged Adults Buying Weed for Ailing Parents (link to PDF–2010) http://www.procon.org/in-the-news-pdfs/parentdish-pot-for-grandma-middle-aged-adults-buying-weed-for-ailing-parents.pdf
- Medical Marijuana Raises Tough Questions for Nursing Homes (news–2010)
http://newoldage.blogs.nytimes.com/2010/10/27/medical-marijuana-raises-tough-questions-in-nursing-homes/
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