ALZHEIMER’S DISEASE / DEMENTIA

ALZHEIMER’S DISEASE / DEMENTIA:

• 2024

• Medicinal Cannabis Extracts are neuroprotective against Aβ amyloid (Aβ)41-mediated toxicity in vitro. https://onlinelibrary.wiley.com/doi/10.1111/bcpt.14078 

• A comprehensive exploration of the multifaceted neuroprotective role of cannabinoids in Alzheimer's Disease across a decade of research.  https://www.mdpi.com/1422-0067/25/16/8630 
• Cannabidiol and neuro-degeneration: from molecular mechanisms to clinical benefits. https://www.sciencedirect.com/science/article/abs/pii/S1568163724002046
• Modulation of oxidative stress and neuroinflammation by cannabidiol (CBD): Promising targets for the treatment of Alzheimer's Disease. https://pubmed.ncbi.nlm.nih.gov/38785534/ 
• Antipsychotics for Dementia tied to more serious harms than expected.  https://jamanetwork.com/journals/jama/article-abstract/2819081 
• "From Stigma to Solution" - Using THC edibles for the palliative treatment of aggression and agitation in Dementia. https://www.sciencedirect.com/science/article/abs/pii/S0885392424003063? 
• Cannabidiol for behavior symptoms in Alzheimer's disease (CANBiS-AD): A randomized, double-blind, placebo-controlled trial. https://www.cambridge.org/core/journals/international-psychogeriatrics/article/cannabidiol-for-behavior-symptoms-in-alzheimers-disease-canbisad-a-randomized-doubleblind-placebocontrolled-trial/7336D30201177E4B080785F055B11E8D 
• Cannabinoids for behavioral symptoms in Dementia: An overview. https://pubmed.ncbi.nlm.nih.gov/38447959/ 
• Caring for Behavioral symptoms of dementia (CBD): A new investigation into cannabidiol (CBD) for the treatment of Anxiety and Agitation in Alzheimer's Dementia. https://www.ajgponline.org/article/S1064-7481(24)00183-0/abstract 
• 2023
• Cannabidiol improves learning and memory deficits and alleviates anxiety in 12 month old SAMP8 Mice. https://www.biorxiv.org/content/10.1101/2023.12.21.572902v1.abstract 
• Interplay between astroglial endocannabinoid system and the cognitive disfunction in Alzheimer's Disease. https://pubmed.ncbi.nlm.nih.gov/38015757/ 
• The use of Dispensary-obtained Tetrahydrocannabinol, as a treatment for neuropsychiatric symptoms of Dementia. https://pubmed.ncbi.nlm.nih.gov/37728481/ 
• Examining the use of cannabidiol and delta 9 tetrahydrocannabinol-based medicine among individuals diagnosed with dementia living within residential aged care facilities: Results of a double blind randomized crossover trial. https://pubmed.ncbi.nlm.nih.gov/37321847/ 
• Under the umbrella of depression and Alzheimer's disease pathophysiology: Can cannabinoids be a Dual pleiotropic therapy? https://www.sciencedirect.com/science/article/pii/S1568163723001575 
• The effect of Cannabidiol 3% on Neuropsychiatric symptoms in Dementia- a six month follow up. https://www.tandfonline.com/doi/abs/10.1080/07317115.2023.2209563 
• The cannabinoids, CBDa and THCa, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer's Disease-like Mouse Model. https://www.mdpi.com/1422-0067/24/7/6827 
• 2022:
• Cannabinoid extract in microdoses ameliorates mnemonic and non-mnemonic Alzheimer's disease symptoms: a case report. https://pubmed.ncbi.nlm.nih.gov/35820856/
• An Ultra-Low dose of delta 9 Tetrahydrocannabinol alleviates Alzheimer's disease-related cognitive impairments and modulates TrkB Receptor Expression in a 5XFAD mouse model. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408848/ 
• Cannabinoids for behavioral symptoms in severe dementia: Safety and Feasibility in a long-term pilot observational study in nineteen patients. https://pubmed.ncbi.nlm.nih.gov/36247984/
• Cannabidiol for neurodegenerative disorders: A comprehensive review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640911/
• 2021
• Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer’s disease:  https://www.sciencedirect.com/science/article/abs/pii/S0223523420301306?via%3Dihub
• A Review on Studies of Marijuana for Alzheimer’s Disease – Focusing on CBD, THC:  http://www.journal-pharm.com/sub/view/301   
• Condition Report: Dementia: https://canneconomy.com/report/condition-report-dementia/
• 2020
• Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission? (Italy/ Netherlands, full, 2020) https://www.mdpi.com/1422-0067/21/3/723/htm 
• Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferatoractivated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease. (Italy, full, 2020) http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=1;spage=67;epage=68;aulast=Brunetti 
• Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. (USA, full, 2020) https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1604-3 
• Adolescent binge-ethanol accelerates cognitive impairment and β-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. (Spain, abstract,  2020) https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12883 

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• 2019
• Plant-Derived THC/CBD Extracts Reduce Dementia Symptoms Per Study (news–2019) https://www.weednews.co/plant-derived-thc-cbd-extracts-reduce-dementia-symptoms-per-study/
• Spontaneous, anecdotal, retrospective, open-label study on the efficacy, safety and tolerability of cannabis galenical preparation (Bedrocan). (Italy, full, 2019) https://onlinelibrary.wiley.com/doi/full/10.1111/ijpp.12514 
• Medical Cannabis for the Treatment of Dementia: A Review of Clinical Effectiveness and Guidelines [Internet]. (Canada, full, 2019) https://www.ncbi.nlm.nih.gov/books/NBK546328/ 
• TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro. (Sweden/ Germany, full, 2019) https://elifesciences.org/articles/37703 
• Anandamide Effects in a Streptozotocin-Induced Alzheimer's Disease-Like Sporadic Dementia in Rats. (Brazil/ Portugal, full, 2019) https://www.frontiersin.org/articles/10.3389/fnins.2018.00653/full 
• How effective and safe is medical cannabis as a treatment of mental disorders? A systematic review. (Germany/ Tanzania, full, 2019) https://link.springer.com/article/10.1007%2Fs00406-019-00984-4 
• 24S-Hydroxycholesterol Is Associated with Agitation Severity in Patients with Moderateto-Severe Alzheimer's Disease: Analyses from a Clinical Trial with Nabilone. (Canada, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839471/ 
• Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer's Disease. (Italy, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667638/ 
• A Review on Studies of Marijuana for Alzheimer's Disease - Focusing on CBD, THC. (Republic of Korea, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970569/ 
• Docosahexaenoic acid,22:6n-3: its roles in the structure and function of the brain. (India/ Finland/ Norway, link to PDF, 2019) https://www.researchgate.net/publication/336635472_Docosahexaenoic_acid226n-3_Its_roles_in_the_structure_and_function_of_the_brain 
• Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease. (USA, abstract, 2019) https://link.springer.com/article/10.1007/s12035-019-1637-8 
• Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson’s disease. (Belgium, abstract, 2019) https://www.semanticscholar.org/paper/Regional-changes-in-the-type-1-cannabinoid-receptor-Ceccarini-Casteels/baafda061e0d91dbd321c0e8125533e94a13552b 
• Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: comparison with geranylated flavonoids, mimulone and diplacone. (Australia/ Japan, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0006295219302990?via%3Dihub 
• Agitation, Oxidative Stress, and Cytokines in Alzheimer Disease: Biomarker Analyses From a Clinical Trial With Nabilone for Agitation. (Canada, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31547752/ 
• The Acute Activation of the CB1 Receptor in the Hippocampus Decreases Neurotoxicity and Prevents Spatial Memory Impairment in Rats Lesioned with β-Amyloid 25-35. (Mexico, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0306452219305433?via%3Dihub 
• Forsythiaside prevents β-amyloid-induced hippocampal slice injury by upregulating 2- arachidonoylglycerol via cannabinoid receptor 1-dependent NF-κB pathway. (China, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0197018618305011?via%3Dihub 
• Dual-Acting Cholinesterase–Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo. (Germany/ Italy/ USA/ France, abstract, 2019) https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00623 
• The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling. (China, abstract, 2019) https://link.springer.com/article/10.1007%2Fs12640-019-00141-8 
• Cannabinoids and the expanded endocannabinoid system in neurological disorders. (Italy/ Canada, abstract, 2019) https://www.nature.com/articles/s41582-019-0284-z 

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• 2018
• ‘Unique’ cannabis compound reverses brain aging in mice. (news – 2018)
  https://www.dw.com/en/unique-cannabis-compound-reverses-brain-aging-in-mice/a-44401750
• Cannabis and the brain: Recent studies shed new light. (news – 2018)
  https://www.medicalnewstoday.com/articles/323673.php
• Microbes, Alzheimer’s Disease, and Cannabis (news–2018)  https://www.uweblesching.com/blog/microbes-alzheimer-s-disease-and-cannabis
• Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users. (Australia, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908414/ 
• Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer's disease. (Spain/ USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968596/ 
• An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. (Italy, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/ 
• Cannabinoids for Behavioural Symptoms in Adults with Dementia: A Review of Clinical Effectiveness and Guidelines. (Spain/ USA, full, 2018) https://www.ncbi.nlm.nih.gov/books/NBK526373/ 
• Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. (Brazil, full, 2018) https://www.frontiersin.org/articles/10.3389/fimmu.2018.02009/full 
• Cannabis Therapeutics and the Future of Neurology. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200872/ 
• Biphasic Effects of THC in Memory and Cognition. (USA/ Mexico, full, 2018) https://onlinelibrary.wiley.com/doi/full/10.1111/eci.12920 
• Modulation of the Cannabinoid System: A New Perspective for the Treatment of the Alzheimer's Disease. (Italy, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343203/ 
• Early Alteration of Distribution and Activity of Hippocampal Type-1 Cannabinoid Receptor in Alzheimer's Disease-like Mice Overexpressing the Human Mutant Amyloid Precursor Protein. (Italy, link to PDF, 2018) https://www.researchgate.net/publication/323198154_Early_Alteration_of_Distribution_and_Activity_of_Hippocampal_Type-1_Cannabinoid_Receptor_in_Alzheimer's_Disease-like_Mice_Overexpressing_the_Human_Mutant_Amyloid_Precursor_Protein 
• GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol. (USA, download, 2018) https://ir.library.louisville.edu/cgi/viewcontent.cgi?article=4093&context=etd 
• Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's disease and Less Well-Known Diseases. (Spain, click “csices” for download, 2018) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22Innovative+Therapeutic+Potential+of+Cannabinoid+Receptors+as+Targets+in+Alzheimer%27s+Disease+and+Less+Well-Known+Diseases.%22&btnG 
• Cannabidiol Reverses Deficits in Hippocampal LTP in a Model of Alzheimer's Disease. (Ireland, click “researchgate” for download, 2018) https://scholar.google.com/scholar?q=%22Cannabidiol+Reverses+Deficits+in+Hippocampal+LTP+in+a+Model+of+Alzheimer%27s+Disease.%22&hl=en&as_sdt=0&as_vis=1&oi=scholart 
• Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system. (Spain, click “open access” then “Dipositubedu” for download, 2018) https://www.semanticscholar.org/paper/Cannabinoid-pharmacology%2Ftherapeutics-in-chronic-Aymerich-As%C3%B3/2e9946a36f70b0f5e320459b0f8f7a7125c72bdc 
• Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer’s Disease. (Spain, abstract, 2018) https://link.springer.com/article/10.1007%2Fs40263-018-0515-7 
• An overview of the cannabinoid type 2 receptor system and its therapeutic potential. (USA, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29794855/ 
• Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer's Disease-Like Pathology. (Germany, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29865078/ 
• Endocannabinoid and Muscarinic Signaling Crosstalk in the 3xTg-AD Mouse Model of Alzheimer's Disease. (Spain/ Belgium, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29865071/ 
• The potential protective effects of cannabinoid receptor agonist WIN55,212-2 on cognitive dysfunction is associated with the suppression of autophagy and inflammation in an experimental model of vascular dementia. (China, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0165178117314798 
• The Down-Expression of ACE and IDE Exacerbates Exogenous Amyloid-β Neurotoxicity in CB2R-/- Mice. (China, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29991137/ 
• Cannabinoids for the treatment of behavioral and psychological symptoms of dementia. (USA, abstract, 2018) https://www.futuremedicine.com/doi/abs/10.2217/nmt-2018-0019?journalCode=nmt& 
• Therapeutic applications of cannabinoids. (India/ Vietnam, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0009279718307373?via%3Dihub 
• Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal model. (Spain, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0006295218303277 
• β-Amyrin, the cannabinoid receptors agonist, abrogates mice brain microglial cells inflammation induced by lipopolysaccharide/interferon-γ and regulates Mφ1/Mφ2 balances. (Iran, abstract,  2018) https://www.sciencedirect.com/science/article/abs/pii/S0753332217358201?via%3Dihub 
• Polyunsaturated fatty acids and endocannabinoids in health and disease. (Brazil, abstract, 2018) https://www.semanticscholar.org/paper/Polyunsaturated-fatty-acids-and-endocannabinoids-in-Freitas-Isaac/678b8d8d196de8c1ba3ea3af9de9f000debfff5c 

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• 2017
• Marijuana could hold the key to treating Alzheimer’s but drug laws stand in the way, say scientists (news–2017) https://www.yahoo.com/news/marijuana-could-hold-key-treating-075000478.html
• Can Marijuana Restore Memory? New Study Shows Cannabis Can Reverse Cognitive Decline in Mice (news–2017) https://www.yahoo.com/news/marijuana-restore-memory-study-shows-150003805.html
• Mice’s aging brains reset to youthful state by cannabinoid (news–2017)  https://arstechnica.com/science/2017/05/in-mice-marijuanas-active-ingredient-reverses-mental-decline-of-age/
• What Marijuana Did For This Alzheimer’s Patient Will Give You Hope (news–2017)  https://thefreshtoast.com/cannabis/what-marijuana-did-for-this-alzheimers-patient-will-warm-your-heart/
• Undeniable Evidence: Cannabis, Alzheimer’s and Dementia (news–2017)
  https://unitedpatientsgroup.com/blog/2017/03/15/undeniable-evidence-cannabis-alzheimers-and-dementia/
• Cannabinoids May Treat Oxidative Stress-Related Neurodegenerative Disorders, Says New Study (news–2017) https://thejointblog.com/cannabinoids-may-treat-oxidative-stress-related-neurodegenerative-disorders-says-new-study/
• Tell Us Your Story: Marijuana Mac & Cheese Helps Ease Alzheimer’s (news–2017)  https://thefreshtoast.com/cannabis/tell-us-your-story-cannabis-mac-cheese-to-help-ease-alzheimers/
• Positive Effects of Medical Marijuana on Alzheimer’s Prevention (news–2017)  https://www.medicalmarijuana.com.au/medical-marijuana/cannabis/positive-effects-of-medical-marijuana-on-alzheimer-s-prevention
• CBD, PPARs, and Gene Expression (news–2017)  https://www.projectcbd.org/science/genetics/cbd-ppars-and-gene-expression
• Marijuana and Alzheimer’s Disease. (news – 2017)
  https://www.leafscience.com/2017/12/22/marijuana-alzheimers-disease/
• Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease. (Puerto Rico/ USA, full, 2017) https://www.frontiersin.org/articles/10.3389/fncel.2016.00294/full 
• Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target. (Italy, full, 2017) https://www.frontiersin.org/articles/10.3389/fnins.2017.00030/full 
• In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease. (Australia, full, 2017) https://www.frontiersin.org/articles/10.3389/fphar.2017.00020/full 
• Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice. (China, full, 2017) https://www.nature.com/articles/s41598-017-02576-5 
• Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid. (Israel, full, 2017) https://www.mdpi.com/1422-0067/18/8/1669/htm 
• New drugs in psychiatry: focus on new pharmacological targets. (Italy, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373420/ 
• A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders. (Singapore, full, 2017) http://www.cpn.or.kr/journal/view.html?volume=15&number=4&spage=301 
• The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases. (Italy, full, 2017) https://www.sciencedirect.com/science/article/pii/S0301008217300709?via%3Dihub 
• Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model. (China, full, 2017) https://www.hindawi.com/journals/ecam/2017/4757520/ 
• Essential Dietary Bioactive Lipids in Neuroinflammatory Diseases. (Italy, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984567/ 
• Endocannabinoid System in Neurodegenerative Disorders. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669051/ 
• MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2. (China, full, 2017) https://www.mdpi.com/1422-0067/20/16/3979/htm 
• Synaptic functions of endocannabinoid signaling in health and disease. (USA/ France/ Italy, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662005/ 
• Neuroprotection in oxidative stress-related neurodegenerative diseases: role of endocannabinoid system modulation. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984569/ 
• Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776068/ 
• Clinical Evidence for Utilizing Cannabinoids in the Elderly. (Israel, link to PDF, 2017) https://www.ima.org.il/MedicineIMAJ/viewarticle.aspx?year=2017&month=02&page=71 
• Activation of CB2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease. (USA, link to PDF, 2017) https://www.researchgate.net/publication/317141246_Activation_of_CB2_receptor_system_restores_cognitive_capacity_and_hippocampal_Sox2_expression_in_a_transgenic_mouse_model_of_Alzheimer's_disease 
• 2-arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals. (Argentina, link to PDF, 2017) https://www.researchgate.net/publication/319300575_2-Arachidonoylglycerol_metabolism_is_differently_modulated_by_oligomeric_and_fibrillar_conformations_of_amyloid_beta_in_synaptic_terminals 
• A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. (Germany/ Israel, click “drperlmutter” for download, 2017) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22A+chronic+low+dose+of+%CE%949-tetrahydrocannabinol+%28THC%29+restores+cognitive+function+in+old+mice%22&btnG
• Neurological aspects of medical use of cannabidiol. (Italy, click “coreacuk” for download, 2017) https://scholar.google.com/scholar?q=Neurological+Aspects+of+Medical+Use+of+Cannabidiol&hl=en&as_sdt=0&as_vis=1&oi=scholart 
• Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. (Spain/ USA, abstract, 2017) https://www.sciencedirect.com/science/article/pii/S0301008216300338 
• Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others? (Italy/ Spain/ Germany, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/28276775/ 
• Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia. (Spain/ Sweden, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0889159117304038?via%3Dihub 
• An update on the advancements in the treatment of agitation in Alzheimer's disease. (USA, abstract, 2017) https://www.tandfonline.com/doi/abs/10.1080/14656566.2017.1307340?journalCode=ieop20& 
• N-stearoyl-l-Tyrosine inhibits the cell senescence and apoptosis induced by H2O2 in HEK293/Tau cells via the CB2 receptor. (China, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0009279716307293 
• GPR3 and GPR6, novel molecular targets for cannabidiol. (USA, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0006291X17310744 
• Perspectives of Cannabinoid type 2 receptor (CB2R) ligands in neurodegenerative disorders: Structure Affinity Relationship (SAfiR) and Structure Activity Relationship (SAR) Studies. (Italy/ Albania, abstract, 2017) https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.7b00155 
• The Use of Cannabinoids in Treating Dementia. (Australia/ UK, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/28631194/ 
• Deletion of Type-2 Cannabinoid Receptor Induces Alzheimer’s Disease-Like Tau Pathology and Memory Impairment Through AMPK/GSK3β Pathway. (China, abstract, 2017) https://link.springer.com/article/10.1007/s12035-017-0676-2 
• Increase in cortical endocannabinoid signaling in a rat model of basal forebrain cholinergic dysfunction. (Spain, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0306452217305663 
• Identification Of Electrophysiological Changes In Alzheimer's Disease: A Microarray Based Transcriptomics And Molecular Pathway Analysis Study. (Saudi Arabia, abstract, 2017) https://www.eurekaselect.com/156521/article 
• Effects of tetrahydrocannabinol on balance and gait in patients with dementia: A randomised controlled crossover trial. (Netherlands, abstract, 2017) https://www.semanticscholar.org/paper/Effects-of-tetrahydrocannabinol-on-balance-and-gait-Elsen-Tobben/a399d1d1ce910ef1181735d5e3f7b72988de442e 
• Cannabinoids for the treatment of neuropsychiatric symptoms, pain and weight loss in dementia. (Canada, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/29256923/ 

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• 2016
• Scientists Want the Smoke to Clear on Medical Marijuana Research (news–2016)  http://www.scientificamerican.com/article/a-new-era-in-medical-marijuana-research/
• Marijuana May Boost Brain Performance (news–2016)
  http://www.worldhealth.net/news/marijuana-may-boost-brain-performance/
• Publix Billionaire Donates $800,000 to Fight Medical Marijuana in Florida (news–2016)
  https://www.yahoo.com/news/publix-billionaire-donates-800-000-205843162.html?nhp=1
• Medical marijuana has potential as Alzheimer’s treatment, study says (news–2016)
  http://kfor.com/2016/07/25/medical-marijuana-has-potential-as-alzheimers-treatment-study-says/
• Does Marijuana Hold the Cure for Alzheimer’s Disease? (news–2016)
  http://www.newsweek.com/marijuana-hold-cure-alzheimers-disease-501687
• Marijuana Use by Older Adults (news–2016)  http://learnaboutmarijuanawa.org/factsheets/olderadults.htm
• Marijuana may help delay Alzheimer’s symptoms (news–2016)  http://psychcentral.com/lib/marijuana-may-help-delay-alzheimers-symptoms/ Microbes,
• THC Stimulates Toxic Plaque Removal in the Brain, Blocks Inflammation, Finds Study (news–2016) http://thejointblog.com/thc-stimulates-toxic-plaque-removal-in-the-brain-blocks-inflammation-finds-study/
• Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells (news–2016) https://www.sciencedaily.com/releases/2016/06/160629095609.htm
• Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to β Amyloid via Protein Kinase C. (China, full, 2016) https://www.hindawi.com/journals/mi/2016/4854378/ 
• Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. (USA/ China, full, 2016) https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0484-z 
• NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2- derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication. (China, full, 2016) https://www.nature.com/articles/srep22429 
• Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview. (Italy, full, 2016) https://www.mdpi.com/1420-3049/21/4/518/htm 
• Modulation of cellular redox homeostasis by the endocannabinoid system. (UK, full, 2016) https://royalsocietypublishing.org/doi/full/10.1098/rsob.150276 
• CB2 Cannabinoid Receptor As Potential Target against Alzheimer's Disease. (Spain, full, 2016) https://www.frontiersin.org/articles/10.3389/fnins.2016.00243/full#B36 
• Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. (Portugal/ Spain/ Argentina, full, 2016) https://www.sciencedirect.com/science/article/pii/S0028390816300879 
• Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. (USA, full,  2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514994/ 
• Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. (Spain/ USA, full, 2016) https://www.frontiersin.org/articles/10.3389/fnins.2016.00406/full 
• Vascular Dysfunction in a Transgenic Model of Alzheimer's Disease: Effects of CB1R and CB2R Cannabinoid Agonists. (Spain, full, 2016) https://www.frontiersin.org/articles/10.3389/fnins.2016.00422/full 
• Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. (Italy, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297661/ 
• Endocannabinoids in Cerebrovascular Regulation. (Hungary/ USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865067/ 
• Agitation in Alzheimer Disease as a Qualifying Condition for Medical Marijuana in the United States. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064815/ 
• Pros and cons of medical cannabis use by people with chronic brain disorders. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652027/ 
• Cannabinoid Receptor 2 Participates in Amyloid-β Processing in a Mouse Model of Alzheimer's Disease but Plays a Minor Role in the Therapeutic Properties of a CannabisBased Medicine. (Spain, link to PDF, 2016) https://www.researchgate.net/publication/295076888_Cannabinoid_Receptor_2_Participates_in_Amyloid-b_Processing_in_a_Mouse_Model_of_Alzheimer's_Disease_but_Plays_a_Minor_Role_in_the_Therapeutic_Properties_of_a_Cannabis-Based_Medicine 
• Metabolomic-Driven Elucidation of Serum Disturbances Associated with Alzheimer's Disease and Mild Cognitive Impairment. (Spain, link to PDF, 2016) https://www.researchgate.net/publication/292388470_Metabolomic-Driven_Elucidation_of_Serum_Disturbances_Associated_with_Alzheimer's_Disease_and_Mild_Cognitive_Impairment 
• Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model. (Spain, link to PDF, 2016) https://www.researchgate.net/publication/306246526_Delineating_the_Efficacy_of_a_Cannabis-Based_Medicine_at_Advanced_Stages_of_Dementia_in_a_Murine_Model 
• Endocannabinoid System in Neurological Disorders. (Italy, link to PDF, 2016) https://www.researchgate.net/publication/304706201_Endocannabinoid_System_in_Neurological_Disorders 
• Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response. (Italy, link to PDF, 2016) https://www.researchgate.net/publication/304361367_Cannabinoids_and_Neuro-Inflammation_Regulation_of_Brain_Immune_Response 
• Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study. (Israel, click “academia” for download, 2016) https://scholar.google.com/scholar?q=Safety+and+Efficacy+of+Medical+Cannabis+Oil+for+Behavioral+and+Psychological+Symptoms+of+Dementia:+An-Open+Label,+Add-On,+Pilot+Study&hl=en&as_sdt=0&as_vis=1&oi=scholart 
• Pharmacological management of agitation and aggression in Alzheimer's Disease: a review of current and novel treatments. (Canada, click “academia” for download, 2016) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22Pharmacological+Management+of+Agitation+and+Aggression+in+Alzheimer%27s+Disease%3A+A+Review+of+Current+and+Novel+Treatments.%22&btnG 
• Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease. (Spain/ USA, click “researchgate” for download, 2016)https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Activity+of+muscarinic%2C+galanin+and+cannabinoid+receptors+in+the+prodromal+and+advanced+stages+in+the+triple+transgenic+mice+model+of+Alzheimer%E2%80%99s+disease&btnG 
• A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia. (Australia, click “uoweduau” for download, 2016) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=A+systematic+review+of+the+effect+of+cannabidiol+on+cognitive+function%3A+Relevance+to+schizophrenia.++++&btnG 
• The emerging role of the cannabinoid receptor family in peripheral and neuro-immune interactions. (Ireland, abstract, 2016) https://www.eurekaselect.com/138448/article 
• Investigational drugs for treating agitation in persons with dementia. (France/ USA, abstract, 2016) https://www.tandfonline.com/doi/abs/10.1080/13543784.2016.1193155 
• Fatty acid amide hydrolase (FAAH), acethylcholinesterase (AChE) and butyrylcholinesterase (BuChE): networked targets for the development of carbamates as potential anti Alzheimer's Disease agents. (Italy, abstract, 2016) https://www.semanticscholar.org/paper/Fatty-Acid-Amide-Hydrolase-(FAAH)%2C-(AChE)%2C-and-for-Montanari-Scalvini/1867be8432971d0209a94ce51e2ecf202b4553cc 
• Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer's disease. (Belgium/ Russia, abstract, 2016)https://link.springer.com/article/10.1007/s00259-016-3457-7 
• Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVDhemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice. (China, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S1074742716301307 
• Type-2 cannabinoid receptors in neurodegeneration. (Italy, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S1043661816306983 
• Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked with Amyotrophic Lateral Sclerosis. (USA, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27714895/ 
• Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism. (Chile/ France, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27757991/         

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• 2015
• How Medical Marijuana’s Chemicals May Protect Cells (news–2015)
  http://www.scientificamerican.com/article/how-medical-marijuana-s-chemicals-may-protect-cells/
• What ailments does medical marijuana help? (news–2015)
  http://www.mnn.com/health/fitness-well-being/stories/what-ailments-does-medical-marijuana-help
• 10 diseases where medical marijuana could have impact (news–2015)
  http://www.cnn.com/2015/04/15/health/marijuana-medical-advances/index.html
• The Science Behind Sanjay Gupta’s WEED 3 (news–2015)
  http://blog.sfgate.com/smellthetruth/2015/04/21/the-science-behind-sanjay-guptas-weed-3/
• Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells. (Finland, full, 2015) https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0305-9 
• Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation. (USA, full, 2015) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129618 
• Potential Therapeutical Contributions of the Endocannabinoid System towards Aging and Alzheimer's Disease. (France/ USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567222/ 
• Narrative review of the safety and efficacy of marijuana for the treatment of commonly state-approved medical and psychiatric disorders. (USA, full, 2015) https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-015-0032-7 
• Safety, pharmacodynamics, and pharmacokinetics of multiple oral doses of delta-9- tetrahydrocannabinol in older persons with dementia. (Netherlands, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480847/ 
• Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications. (Spain, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604192/ 
• Marijuana Legalization: Impact on Physicians and Public Health. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900958/ 
• The basolateral amygdala γ-aminobutyric acidergic system in health and disease. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837071/ 
• Analysis of calretinin early expression in the rat hippocampus after beta amyloid (1-42) peptide injection. (Italy, link to PDF, 2015) https://www.researchgate.net/publication/274257872_Analysis_of_calretinin_early_expression_in_the_rat_hippocampus_after_beta_amyloid_1-42_peptide_injection 
• The role of cannabinoids and leptin in neurological diseases. (Turkey, link to PDF, 2015) https://www.researchgate.net/publication/287360490_The_role_of_cannabinoids_and_endocannabinoid_system_in_the_treatment_of_epilepsy 
• Endocannabinoids and Neurodegenerative Disorders: Parkinson's Disease, Huntington's Chorea, Alzheimer's Disease, and Others. (Spain, download, 2015) https://www.cannabismedicinal.com.ar/images/documentos/Investigacion/ChapterPertwee_2015.pdf 
• WIN 55,212-2, Agonist of Cannabinoid Receptors, Prevents Amyloid β1-42 Effects on Astrocytes in Primary Culture. (Spain, download, 2015) https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122843&type=printable 
• Cannabinoids in late-onset Alzheimer's disease. (Netherlands, click “medicinalgenomics” for download, 2015) https://scholar.google.com/scholar?q=Cannabinoids+in+late-onset+Alzheimer%27s+disease.&hl=en&as_sdt=0&as_vis=1&oi=scholart 
• Endocannabinoid regulation of amyloid-induced neuroinflammation. (Spain/ USA, click “ufves” for download, 2015) https://scholar.google.com/scholar?q=Endocannabinoid+regulation+of+amyloid-induced+neuroinflammation&hl=en&as_sdt=0&as_vis=1&oi=scholart 
• Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model. (Germany, click “unibonnde” for download, 2015) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Cannabinoid+receptor+2+deficiency+results+in+reduced+neuroinflammation+in+an+Alzheimer%27s+disease+mouse+model&btnG 
• N-stearoyltyrosine protects primary cortical neurons against Aβ(1-40)-induced injury through inhibiting endocannabinoid degradation. (China, abstract, 2015) https://www.sciencedirect.com/science/article/abs/pii/S0024320515000521 
• Elevation of Plasma 2-Arachidonoylglycerol Levels in Alzheimer's Disease Patients as a Potential Protective Mechanism against Neurodegenerative Decline. (Italy, abstract, 2015) https://pubmed.ncbi.nlm.nih.gov/25818503/ 
• Monoacylglycerol Lipase Inhibitor Protects Primary Cultured Neurons Against Homocysteine-induced Impairments in Rat Caudate Nucleus through COX-2 signaling. (China, abstract, 2015) https://www.semanticscholar.org/paper/Endocannabinoid-2-Arachidonylglycerol-Protects-in-Dong-Lu/51faf86471136683da6bfc2e9cf770392880b5a9 
• Advancements in the treatment of agitation in Alzheimer's disease. (USA, abstract, 2015) https://pubmed.ncbi.nlm.nih.gov/26159445/ 
• Effect of Homocysteine on Voltage-Gated Sodium Channel Currents in Primary Cultured Rat Caudate Nucleus Neurons and Its Modulation by 2-Arachidonylglycerol. (China, abstract, 2015) https://www.semanticscholar.org/paper/Effect-of-Homocysteine-on-Voltage-Gated-Sodium-in-Zou-Lu/cee8228eb41dfb6a0bc6192e72e1d4122d4fc6fd 
• Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer's Disease. (Canada, abstract, 2015) https://pubmed.ncbi.nlm.nih.gov/26271310/ 
• Pharmacological benefits of selective modulation of cannabinoid receptor type 2 (CB2) in experimental Alzheimer's disease. (India, abstract, 2015) https://www.sciencedirect.com/science/article/pii/S0091305715300952 
• Characterization of Lignanamides from Hemp (Cannabis sativa L. ) Seed and their Antioxidant and Acetylcholinesterase Inhibitory Activities. (China/ Switzerland, abstract, 2015) https://pubs.acs.org/doi/10.1021/acs.jafc.5b05282 

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• 2014
• Marijuana for Alzheimer’s Disease (news–2014)
  https://www.psychologytoday.com/blog/your-brain-food/201411/marijuana-alzheimer-s-disease
• Blocking brain’s ‘internal marijuana’ may trigger early Alzheimer’s deficits, study shows (news–2014) http://medicalxpress.com/news/2014-06-blocking-brain-internal-marijuana-trigger.html
• Marijuana compound may offer treatment for Alzheimer’s disease (news–2014)
  http://medicalxpress.com/news/2014-08-marijuana-compound-treatment-alzheimer-disease.html
• Marijuana fights Alzheimer’s disease, new study indicates (news–2014)
  http://blog.sfgate.com/smellthetruth/2014/11/29/marijuana-fights-alzheimers-disease-study-indicates/
• Marijuana compound may halt Alzheimer’s disease – study (news–2014)
  http://rt.com/news/183948-marijuana-compound-stop-alzheimer/
• 4 Mind Blowing Ways Cannabis Can Help Your Brain (news–2014)  https://www.medicaljane.com/2014/12/14/4-mind-blowing-ways-marijuana-can-help-your-brain/

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• 2013
• Medical marijuana helps senior sleep, contend with other problems of aging (news–2013)
  http://www.ottawacitizen.com/health/seniors/Medical+marijuana+helps+senior+sleep+contend+with+other/8439474/story.html
• Terpenes May Improve Effectiveness Of Medical Marijuana (news–2013)
  http://www.medicaljane.com/2013/09/23/terpenes-may-improve-effectiveness-of-medical-marijuana/#
• Marijuana may improve stamina, rejuvenate brain – study (news-2013)
  http://www.gmanetwork.com/news/story/312937/scitech/science/marijuana-may-improve-staminarejuvenate-brain-study
• Marijuana cannabinoids slow brain degradation and aging, reverse dementia: here’s how (news–2013)  http://www.naturalnews.com/040456_marijuana_cannabinoids_dementia.html
• Drug War Blocking Potential Treatments for Cancer, Alzheimer’s, Journal Claims (news–2013) http://healthland.time.com/2013/06/14/drug-war-blocking-potential-treatments-for-cancer-alzheimers-journal-claims/

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• 2012
• Can Marijuana Prevent Alzheimer’s? (news–2012) http://www.nextavenue.org/can-marijuana-save-aging-brain/
• How Cannabinoids May Slow Brain Aging (news–2012)
  http://healthland.time.com/2012/10/29/how-cannabinoids-may-slow-brain-aging/
• Cannabinoid Receptor Stimulator Reverses Symptoms of Alzheimer’s Disease in Animal Model (news–2012) http://www.biotechdaily.com/?option=com_article&Itemid=294742494
• Researchers investigating potential drug for treatement of Alzheimer’s disease (news–2012) http://medicalxpress.com/news/2012-08-potential-drug-treatement-alzheimer-disease.html
• Research identifies new therapeutic target for Alzheimer’s disease (news–2012)
  http://medicalxpress.com/news/2012-11-therapeutic-alzheimer-disease.html

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• 2011
• Bodyguard for the Brain: Researchers Identify Mechanism That Seems to Protect Brain
  from Aging (news–2011) http://www.sciencedaily.com/releases/2011/07/110712093856.htm

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• 2010
• Newly discovered mechanism controls levels and efficacy of a marijuana-like substance in the brain (news–2010)
  http://www.eurekalert.org/pub_releases/2010-08/uow-ndm080610.php
• Cannabis and Alzheimer’s Disease (news–2010)  http://www.amarimed.com/DOCBLOG/tabid/90/EntryId/16/Cannabis-and-Alzheimers-Disease.aspx
• Cannabinoids in Alzheimer’s Disease, Part II (news–2010)  http://www.amarimed.com/DOCBLOG/tabid/90/EntryId/17/Cannabinoids-in-Alzheimer-s-Disease-Part-II.aspx

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