DIABETES 

DIABETES:

• 2023
• Association between Cannabis use and risk of Diabetes Mellitus type 2: A systematic review and meta analysis. https://onlinelibrary.wiley.com/doi/10.1002/ptr.7973 
• Cannabidiol ameliorates inflammatory response partly by AGE-RAGE pathway in Diabetic Mice. https://onlinelibrary.wiley.com/doi/10.1002/ddr.22093 
• Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels:  https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.15020
• 2020
• Spice intoxication and hyperglycemia. (Spain, abstract in English, link to full in Spanish, 2020) https://pubmed.ncbi.nlm.nih.gov/31999272/ 
• Involvement of endocannabinoid system, inflammation and apoptosis in diabetes induced liver injury: Role of 5-HT3 receptor antagonist. (Iran, abstract, 2020) https://www.sciencedirect.com/science/article/pii/S1567576919322684 
• 2019
• Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome. (Israel, full, 2019) https://www.mdpi.com/2072-6651/11/5/275/htm 
• Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment. (USA, full, 2019) https://www.frontiersin.org/articles/10.3389/fendo.2019.00311/full 
• Endocannabinoid System in Hepatic Glucose Metabolism, Fatty Liver Disease, and Cirrhosis. (Germany, full, 2019) https://www.mdpi.com/1422-0067/20/10/2516/htm 
• Stress during Lactation Induces Insulin Resistance Associated with an Increase in Type 1 Cannabinoid Receptors in Liver and Adipose Tissue. (Chile, full, 2019) https://www.hindawi.com/journals/jnme/2019/2806519/ 
• Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells. (China, full, 2019) https://www.sciencedirect.com/science/article/pii/S0753332218375668?via%3Dihub 
• Joint and separate exposure to alcohol and ∆9-tetrahydrocannabinol produced distinct effects on glucose and insulin homeostasis in male rats. (USA, full, 2019) https://www.nature.com/articles/s41598-019-48466-w 
• Do Endocannabinoids Regulate Glucose Reabsorption in the Kidney? (Israel, full, 2019) https://www.karger.com/Article/FullText/494512 
• Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis. (Austria, full, 2019) https://www.sciencedirect.com/science/article/pii/S0098299718300748?via%3Dihub 
• Altered cannabinoid receptor expression in pancreatic islets in experimental model of uremia. (Poland, full, 2019) https://journals.viamedica.pl/folia_morphologica/article/view/64828 
• Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to DietInduced Obesity in Mice. (Canada/ Italy, full, 2019) https://msystems.asm.org/content/4/6/e00407-19 
• The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases. (Italy, full, 2019) https://www.mdpi.com/1422-0067/20/23/5875/htm 
• Medical marijuana—an obesity problem or opportunity? (USA, article, 2019) https://www.nature.com/articles/s41366-019-0334-z 
• Endocannabinoid Signalling in Atherosclerosis and Related Metabolic Complications. (Germany, 1st page, 2019) https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1678738 
• Diet-Induced Obesity in Cannabinoid-2 Receptor Knockout Mice and Cannabinoid Receptor 1/2 Double-Knockout Mice. (USA, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/30699233/ 
• The effects of delta-9-tetrahydrocannabinol on Krüppel-like factor-4 expression, redox homeostasis, and inflammation in the kidney of diabetic rat. (Turkey, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31081965/ 
• Lifetime marijuana use in relation to insulin resistance in lean, overweight, and obese US adults. (Canada, abstract, 2019) https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12958 
• Impact of lifetime marijuana use on fasting plasma insulin levels and HOMA-IR score in obese adults with and without insulin resistance. (Canada, abstract, 2019) https://link.springer.com/article/10.1007/s00592-019-01390-x 
• Diet, endocannabinoids, and health. (USA, abstract, 2019) https://www.sciencedirect.com/science/article/pii/S027153171930572X?via%3Dihub 
• Cannabidiol improves metabolic dysfunction in middle-aged diabetic rats submitted to a chronic cerebral hypoperfusion. (Brazil, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S000927971930701X?via%3Dihub 
• Therapeutic potential of cannabinoid receptor 2 in the treatment of diabetes mellitus and its complications. (India, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0014299919305801 
• Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues. (Germany, abstract, 2019) https://link.springer.com/article/10.1007%2Fs00018-018-2994-6 
• The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus. (Canada, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31686231/ 
• Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity. (Spain/ Italy, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0006295219303922?via%3Dihub
• The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities. (USA, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31793418/ 
• 2018
• Cannabis Compound Eyed As Possible Diabetes Treatment (news–2018)  https://fox13now.com/2018/12/29/cannabis-compound-eyed-as-possible-diabetes-treatment/
• Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes. (Netherlands, full, 2018) https://www.nature.com/articles/s41387-017-0016-7 
• Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells. (Republic of Korea/ USA, full, 2018) https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.13523 
• Protective Effects of Gomisin N against Hepatic Cannabinoid Type 1 Receptor-Induced Insulin Resistance and Gluconeogenesis. (Republic of Korea, full, 2018) https://www.mdpi.com/1422-0067/19/4/968/htm 
• The Role of Gut Microbiota in Obesity and Type 2 and Type 1 Diabetes Mellitus: New Insights into "Old" Diseases. (Germany, full, 2018) https://www.mdpi.com/2076-3271/6/2/32/htm 
• Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders (France/ Belgium, full, 2018) https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22175 
• LH-21, A Peripheral Cannabinoid Receptor 1 Antagonist, Exerts Favorable Metabolic Modulation Including Antihypertensive Effect in KKAy Mice by Regulating Inflammatory Cytokines and Adipokines on Adipose Tissue. (China, full, 2018) https://www.frontiersin.org/articles/10.3389/fendo.2018.00167/full 
• Profiling plasma N-Acylethanolamine levels and their ratios as a biomarker of obesity and dysmetabolism. (Italy, full, 2018) https://www.sciencedirect.com/science/article/pii/S2212877818303934?via%3Dihub 
• Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive. (USA, full, 2018) https://www.frontiersin.org/articles/10.3389/fnmol.2018.00214/full 
• The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCASalt Model of Hypertension. (Poland, full, 2018) https://www.karger.com/Article/FullText/488730 
• Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar dietinduced beta cell dysfunction and inflammation in murine islets. (USA, full, 2018) https://link.springer.com/article/10.1007/s00125-018-4576-4 
• Peripheral CB1 Receptor Neutral Antagonist, AM6545, Ameliorates Hypometabolic Obesity and Improves Adipokine Secretion in Monosodium Glutamate Induced Obese Mice. (China, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869198/ 
• Involvement of TRPV1 Channels in Energy Homeostasis. (Australia, full, 2018) https://www.frontiersin.org/articles/10.3389/fendo.2018.00420/full 
• Primary Causes of Hospitalizations and Procedures, Predictors of In-hospital Mortality, and Trends in Cardiovascular and Cerebrovascular Events Among Recreational Marijuana Users: A Five-year Nationwide Inpatient Assessment in the United States. (USA/ Curacau/ Russia, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200442/ 
• Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII and ApoE in humans consuming high fructose corn syrup-sweetened beverage. (USA, full, 2018) https://journals.physiology.org/doi/full/10.1152/ajpendo.00406.2017 
• Prevalence of alcohol, tobacco, cannabis and other illicit substance use in a population of Canadian adolescents with type 1 diabetes compared to a general adolescent population. (Canada, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951101/ 
• Endocannabinoids in Islets of Langerhans: The Ugly, the Bad and the Good Facts. (USA, full, 2018) https://journals.physiology.org/doi/full/10.1152/ajpendo.00338.2017 
• GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues. (UK, full, 2018) https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201800171R 
• Time-dependent effect of phytocannabinoid treatments in fat cells. (South Africa, full, 2018) https://onlinelibrary.wiley.com/doi/full/10.1002/ptr.6047 
• Association Between Cannabis Use and Risk for Diabetic Ketoacidosis in Adults With Type 1 Diabetes. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583413/ 
• Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics. (Sweden/ Italy/ UK/ Finland/ Netherlands/ France, link to PDF, 2018) https://www.researchgate.net/publication/321784276_Increased_Levels_of_Circulating_Fatty_Acids_Are_Associated_with_Protective_Effects_against_Future_Cardiovascular_Events_in_Nondiabetics 
• Sub-chronic treatment with cannabidiol but not with URB597 induced a mild antidepressant-like effect in diabetic rats. (Brazil, link to PDF, 2018) https://www.researchgate.net/publication/325609091_Sub-chronic_treatment_with_cannabidiol_but_not_with_URB597_induced_a_mild_antidepressant-like_effect_in_diabetic_rats 
• The effects of cannabinoids on the endocrine system. (Poland, link to PDF, 2018) https://journals.viamedica.pl/endokrynologia_polska/article/view/58487 
• Genetic polymorphisms of the endocannabinoid system in obesity and diabetes. (UK, link to PDF, 2018) https://www.researchgate.net/publication/327161214_Genetic_Polymorphisms_of_the_Endocannabinoid_System_in_Obesity_and_Diabetes 
• Peripheral cannabinoid 1 receptor blockade mitigates adipose tissue inflammation via NLRP3 inflammasome in mouse models of obesity. (Republic of Korea, click “researchgate” for download, 2018) https://scholar.google.com/scholar?cluster=14526334963487230700&hl=en&as_sdt=0,5&as_vis=1 
• Cannabinoid Receptors in Diabetic Kidney Disease. (Italy, click “unitoit” for download, 2018) https://scholar.google.com/scholar?q=Cannabinoid+Receptors+in+Diabetic+Kidney+Disease&hl=en&as_sdt=0&as_vis=1&oi=scholart 
• Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol. (Italy, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0367326X17317598 
• Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor. (China, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29699000/ 
• The role of cannabinoid signaling in acute and chronic kidney diseases. (Italy, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29706358/ 
• Is Cannabidiol a Promising Substance for New Drug Development? A Review of its Potential Therapeutic Applications. (Pakistan, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29773016/ 
• Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice. (Japan/ USA, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/30265576/ 
• The relationship between cannabis use and diabetes: Results from the National Epidemiologic Survey on Alcohol and Related Conditions III. (Canada/ Germany, abstract, 2018) https://onlinelibrary.wiley.com/doi/abs/10.1111/dar.12867 
• Endocannabinoid hydrolase and cannabinoid receptor 1 are involved in the regulation of hypothalamus-pituitary-adrenal axis in type 2 diabetes. (China, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29948652/ 
• Effects of Cannabidiol on Diabetes Outcomes and Chronic Cerebral Hypoperfusion Comorbidities in Middle-Aged Rats. (Brazil, abstract, 2018) https://link.springer.com/article/10.1007%2Fs12640-018-9972-5 
• Polyunsaturated fatty acids and endocannabinoids in health and disease. (Brazil, abstract, 2018) https://www.semanticscholar.org/paper/Polyunsaturated-fatty-acids-and-endocannabinoids-in-Freitas-Isaac/678b8d8d196de8c1ba3ea3af9de9f000debfff5c 
• 2017
• Active ingredients in both hot peppers and cannabis calm the gut’s immune system (news–2017) https://medicalxpress.com/news/2017-04-ingredients-hot-peppers-cannabis-calm.html
• Chili peppers, marijuana may reduce gut inflammation (news–2017) http://www.medicalnewstoday.com/articles/317128.php
• To Calm the Gut, Look to Weed and Hot Peppers (news–2017) https://www.inverse.com/article/30714-marijuana-weed-spicy-food-gut
• Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat. (Ireland/ Italy, full, 2017) https://www.nature.com/articles/srep43300 
• We are not alone: a case for the human microbiome in extra intestinal diseases. (India, full, 2017) https://gutpathogens.biomedcentral.com/articles/10.1186/s13099-017-0163-3 
• Endocannabinoid system acts as a regulator of immune homeostasis in the gut. (USA, full, 2017) https://www.pnas.org/content/early/2017/04/18/1612177114.long 
• Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice. (China, full, 2017) https://www.nature.com/articles/s41598-017-02576-5 
• The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice. (Spain/ UK/ Brazil, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479807/ 
• Interactions between gut microbes and host cells control gut barrier and metabolism. (Belgium, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485881/ 
• Daytime-Dependent Changes of Cannabinoid Receptor Type 1 and Type 2 Expression in Rat Liver. (Germany, full, 2017) https://www.mdpi.com/1422-0067/18/9/1844/htm 
• Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study. (USA/ Canada, full, 2017) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176416 
• GPR55: a new promising target for metabolism? (Spain/ Norway, full, 2017) https://jme.bioscientifica.com/view/journals/jme/58/3/R191.xml 
• Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. (Germany/ France/ Italy/ USA, full, 2017) https://www.jci.org/articles/view/83626 
• MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future. (France, full, 2017) https://eje.bioscientifica.com/view/journals/eje/176/6/R309.xml 
• Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type-2 Diabetes. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360301/ 
• Overactivation of the endocannabinoid system alters the anti-lipolytic action of insulin in mouse adipose tissue. (France, full, 2017) https://journals.physiology.org/doi/full/10.1152/ajpendo.00374.2016 
• The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice. (Spain, full, 2017) https://www.mdpi.com/1422-0067/18/11/2268/htm 
• A TRPV1‐to‐secretagogin regulatory axis controls pancreatic β‐cell survival by modulating protein turnover. (Austria/ Sweden/ Italy/ Hungary, full, 2017) https://www.embopress.org/doi/full/10.15252/embj.201695347 
• Incretin Secretion in Humans is under the Influence of Cannabinoid Receptors. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625085/ 
• Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance. (USA, full, 2017) https://escholarship.org/uc/item/3x70w0hv 
• Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy. (Israel, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791066/ 
• Role of Endocannabinoids on Sweet Taste Perception, Food Preference, and Obesity-related Disorders. (Spain/ Germany, full, 2017) https://academic.oup.com/chemse/article/43/1/3/4411748 
• 2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes. (Netherlands, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409477/ 
• GPR55 and the regulation of glucose homeostasis. (Spain, link to PDF, 2017) https://www.researchgate.net/publication/316529366_GPR55_and_the_regulation_of_glucose_homeostasis 
• Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy. (USA, PDF, 2017) http://publicatio.bibl.u-szeged.hu/13595/1/Jourdan_DiabetesObsityMetabolism_2017.pdf 
• LH-21 and Abn-CBD improve β-cell function in isolated human and mouse islets through GPR55-dependent and -independent signalling. (UK/ Spain, link to download, 2017) https://kclpure.kcl.ac.uk/portal/files/97046207/data_proof_2.pdf 
• Diabetes Management by Probiotics: Current Knowledge and Future Pespective. (Iran, click “researchgate” for download, 2017) https://scholar.google.com/scholar?q=Diabetes+Management+by+Probiotics:+Current+Knowledge+and+Future+Perspective&hl=en&as_sdt=0&as_vis=1&oi=scholart 
• Metabolic Syndrome Induced Bladder Cannabinoid Receptor Changes in the FructoseFed Rats. (Taiwan, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/28386998/ 
• High-Throughput Screening and Bioinformatic Analysis to Ascertain Compounds that Prevent Saturated Fatty Acid-Induced β-Cell Apoptosis. (USA/ Belgium/ Italy, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0006295217302575 
• CB-1R and GLP-1R gene expressions and oxidative stress in the liver of diabetic rats treated with sitagliptin. (Turkey, abstract, 2017) https://link.springer.com/article/10.1016%2Fj.pharep.2017.03.013 
• Polymorphism rs3123554 in the cannabinoid receptor gene type 2 (CNR2) reveals effects on body weight and insulin resistance in obese subjects. (Spain, abstract in English & Spanish, 2017) https://www.sciencedirect.com/science/article/abs/pii/S2530016417301799 
• Re-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases. (USA, abstract, 2017) https://link.springer.com/article/10.1007%2Fs11892-017-0924-x
• In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor. (Japan, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/29017758/ 
• 2016
• Foot Nail Fungus is Stubborn, Ugly, and Pernicious (news–2016) http://cannabishealthindex.com/cannabinoid-research/foot-nail-fungus-is-stubborn-ugly-and-pernicious/
• Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells. (Republic of Korea/ USA, full, 2016) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150981 
• New insights into the yin and yang of the endocannabinoid system in health and disease. (UK, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341336/ 
• Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. (Spain, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902197/ 
• Metabolic Syndrome Among Marijuana Users in the United States: An Analysis of National Health and Nutrition Examination Survey Data. (USA, full, 2016) https://www.amjmed.com/article/S0002-9343(15)01024-4/fulltext 
• Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679742/ 
• CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction. (UK/ China, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783351/ 
• Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction. (UK/ Mexico, full, 2016) https://www.sciencedirect.com/science/article/pii/S2214647416300137 
• The effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats. (Iran, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887712/ 
• Endocannabinoids in Feeding Behavior and Energy Homeostasis. (USA, full, 2016) http://themedicalbiochemistrypage.org/endocannabinoids-in-feeding-behavior-and-energy-homeostasis/ 
• Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism. (USA, full, 2016) https://www.nature.com/articles/srep33302 
• Cannabis Use as Risk or Protection for Type 2 Diaditudinal Study of 18 000 Swedish Men and Women. (Sweden, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098083/ 
• Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance. (Sweden, full, 2016) https://link.springer.com/article/10.1007/s12020-016-1172-6 
• Cannabinoid 2 Receptor Agonist Improves Systemic Sensitivity to Insulin in High-Fat Diet/Streptozotocin-Induced Diabetic Mice. (China, full, 2016) https://www.karger.com/Article/FullText/453171 
• α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. (Canada, full, 2016) https://www.cell.com/cell-reports/fulltext/S2211-1247(16)31373-0 
• Endocannabinoid regulation of β-cell functions: Implications for glycemic control and diabetes. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045244/ 
• Early Low Fat Diet Enriched with Linolenic Acid Reduces Liver Endocannabinoid Tone and Improves Late Glycemic Control After a High Fat Diet Challenge in Mice. (France/ Italy, full, 2016) https://diabetes.diabetesjournals.org/content/65/7/1824.long 
• Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, PlaceboControlled, Parallel Group Pilot Study. (UK, full, 2016) https://care.diabetesjournals.org/content/39/10/1777.long 
• Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. (China, full, 2016) https://www.hindawi.com/journals/bmri/2016/9782031/ 
• Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas. (Japan, full, 2016) https://jpet.aspetjournals.org/content/357/1/217.long 
• Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. (Portugal/ USA, link to PDF, 2016) https://www.researchgate.net/publication/303358549_Hierarchical_glucocorticoid-endocannabinoid_interplay_regulates_the_activation_of_the_nucleus_accumbens_by_insulin 
• Effects of activation of endocannabinoid system on myocardial metabolism. (Poland, link to PDF, 2016) https://www.semanticscholar.org/paper/Effects-of-activation-of-endocannabinoid-system-on-Polak-Harasim/0c89f0505a105bf88c1afc13880cdf741c7be10b 
• Cannabinoid receptors and TRPA1 on neuroprotection in a model of retinal ischemia. (Brazil, download, 2016) http://innt.org.br/wp-content/uploads/2017/07/Receptores-canabino%CC%81ides-e-TRPA1-em-neuroprotec%CC%A7a%CC%83o-em-um-modelo-de-isquemia-da-retina.pdf 
• Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy. (Portugal/ Italy, link to download, 2016) https://www.academia.edu/31960981/Endovanilloid_control_of_pain_modulation_by_the_rostroventromedial_medulla_in_an_animal_model_of_diabetic_neuropathy 
• Cannabinoids and autoimmune diseases: A systematic review. (Israel, click “cedfoundation” for download, 2016) https://static1.squarespace.com/static/5dab51c52920995e635d4295/t/5e146a8d01a8570f0faef6c5/1578396305883/Katchan2016AutoimmunityReviews.pdf 
• Impaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathy. (Ireland, click “nuigalwayie” for download, 2016) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%27Impaired+cued+and+spatial+learning+performance+and+altered+cannabinoid+CB1+receptor+functionality+in+the+substantia+nigra+in+a+rat+model+of+diabetic+neuropathy%22&btnG 
• GPR55-dependent stimulation of insulin secretion from isolated mouse and human islets of Langerhans. (UK, link to download, 2016) https://kclpure.kcl.ac.uk/portal/files/58649551/Liu_et_al_2016_Diabetes_Obesity_and_Metabolism.pdf 
• Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity. (Taiwan, Abstract, 2016) https://www.semanticscholar.org/paper/Cannabinoid-receptor-type-1-mediates-high-fat-by-O1-Chen-Lee/fbc86478aad4611831983cc0250ea092270fa934 
• Role of cannabinoid receptors in renal diseases. (France, abstract in English & French, 2016) https://www.sciencedirect.com/science/article/abs/pii/S1769725516000353 
• G protein-coupled receptor 18: A potential role for endocannabinoid signalling in metabolic dysfunction. (Australia, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/26337420/ 
• Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors. (Brazil, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S0924977X1630164X 
• β-Caryophyllene, a natural sesquiterpene lactone attenuates hyperglycemia mediated oxidative and inflammatory stress in experimental diabetic rats. (India, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S000927971530154X 
• The role of carbon monoxide on the anti-nociceptive effects and expression of cannabinoid 2 receptors during painful diabetic neuropathy in mice. (Spain, abstract, 2016) https://www.semanticscholar.org/paper/The-role-of-carbon-monoxide-on-the-anti-nociceptive-Castany-Carcol%C3%A9/e571a6abe2ccf6bd4be94a52bc9252393588a522 
• Marijuana Use and Type 2 Diabetes Mellitus: a Review. (USA, abstract, 2016) https://link.springer.com/article/10.1007%2Fs11892-016-0795-6 
• Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes. (Canada, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27767974/ 
• Cannabinoid receptors in the kidney. (Australia, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27367912/ 
• 2015
• Smoking Cannabis Reduces Diabetic Neuropathy Pain (news & abstract-2015) http://neurosciencenews.com/diabetic-neuropathy-marijuana-neurology-2287/
• Marijuana Could Be the Answer to Fighting These 3 Diseases (news-2015) (may require free registration) http://www.fool.com/investing/general/2015/01/10/marijuana-could-be-the-answer-to-fighting-these-3.aspx
• New study links marijuana use and low body weight among Nunavik Inuit (news-2015) http://www.nunatsiaqonline.ca/stories/article/65674new_study_links_marijuana_use_and_low_body_weight_among_inuit/
• What ailments does medical marijuana help? (news-2015) http://www.mnn.com/health/fitness-well-being/stories/what-ailments-does-medical-marijuana-help
• Cannabis alleviates peripheral neuropathic pain in diabetes (news-2015) http://medicalxpress.com/news/2015-07-cannabis-alleviates-peripheral-neuropathic-pain.html
• Marijuana Gains Traction In Fight Against Diabetes And Obesity (news–2015) http://finance.yahoo.com/news/marijuana-gains-traction-fight-against-113820923.html
• Why THC Isn’t The Only Thing In Weed That Matters (news–2015) http://www.refinery29.com/2015/08/92201/cbd-medical-marijuana-facts#.d3jbvn:v7pE
• Synthetic cannabis compounds used to tackle diabetes linked kidney failure (news–2015) http://www.heraldscotland.com/news/14031326.Synthetic_cannabis_compounds_used_to_tackle_diabetes_linked_kidney_failure/?ref=rss
• Infographic: Pot smokers are skinnier than non-users (news–2015) http://o.canada.com/health-2/infographic-pot-smokers-are-skinnier-than-non-users
• Endogenous “cannabis” influences development of the fetal pancreas (news-2015) https://www.sciencedaily.com/releases/2015/10/151023084458.htm
• Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and NPalmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis. (UK, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385619/ 
• Atypical diabetic ketoacidosis: case report. (Turkey, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342127/ 
• Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons. (Finland/ Italy, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423197/ 
• Diacylglycerol lipase α knockout mice demonstrate metabolic and behavioral phenotypes similar to those of cannabinoid receptor 1 knockout mice. (USA, full, 2015) https://www.frontiersin.org/articles/10.3389/fendo.2015.00086/full 
• Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation. (UK, full, 2015) https://academic.oup.com/cardiovascres/article/107/4/568/311617 
• Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. (Brazil/ Italy, full, 2015) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142728 
• Cannabinoid CB1 receptors and mTORC1 signalling pathway interact to modulate glucose homeostasis. (Spain/ France, full, 2015) https://dmm.biologists.org/content/9/1/51.long 
• Cannabis Use and Reduced Risk of Insulin Resistance in HIV-HCV Infected Patients: A Longitudinal Analysis (ANRS CO13 HEPAVIH). (France, full, 2015) https://academic.oup.com/cid/article/61/1/40/340299 
• Dietary DHA reduced downstream endocannabinoid and inflammatory gene expression, epididymal fat mass, and improved aspects of glucose use in muscle in C57BL/6J mice. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722239/ 
• Renal effects of chronic pharmacological manipulation of CB2 receptors in rats with diet-induced obesity. (Australia, full, 2015) https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13056 
• Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424182/ 
• Cannabis Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801109/ 
• Role of the Endocannabinoid System in Diabetes and Diabetic Complications. (Italy/ USA, full, 2015) https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13226 
• Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152762/ 
• Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. (Taiwan, full, 2015) https://www.fertstert.org/article/S0015-0282(15)00232-0/fulltext 
• CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609878/ 
• Marijuana use and risk of prediabetes and diabetes by middle adulthood: the Coronary Artery Risk Development in Young Adults (CARDIA) study. (USA, full, 2015) https://link.springer.com/article/10.1007/s00125-015-3740-3 
• Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. (Belgium/ France, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382707/ 
• Blockade of Cannabinoid 1 Receptor Improves GLP-1R Mediated Insulin Secretion in Mice (USA/ Republic of Korea, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752920/ 
• Endocannabinoids - at the crossroads between the gut microbiota and host metabolism. (Belgium, link to PDF, 2015) https://www.researchgate.net/publication/287327687_Endocannabinoids_-_at_the_crossroads_between_the_gut_microbiota_and_host_metabolism 
• Endocannabinoids and Metabolic Disorders. (France, partial preview, 2015) https://books.google.com/books?hl=en&lr=&id=QwihCgAAQBAJ&oi=fnd&pg=PA367&ots=FMMqBvBXpz&sig=UcKSevqXmHZ58q2-o7wctGRBdNM#v=onepage&q&f=false 
• N-Oleoyl glycine, a lipoamino acid, stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte. (China, link to PDF, 2015) https://www.researchgate.net/publication/281780501_N-Oleoyl_glycine_a_lipoamino_acid_stimulates_adipogenesis_associated_with_activation_of_CBI_receptor_and_Akt_signaling_pathway_in_3T3-L1_adipocyte 
• Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy. (Poland, abstract, 2015) https://www.sciencedirect.com/science/article/abs/pii/S1734114014002849 
• Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model. (Taiwan, abstract, 2015) https://www.sciencedirect.com/science/article/abs/pii/S0006291X15006233 
• Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: interaction with glutamatergic functions. (Japan, abstract, 2015) https://www.sciencedirect.com/science/article/abs/pii/S0014488615001260 
• Death due to diabetic ketoacidosis: Induction by the consumption of synthetic cannabinoids? (Germany, abstract, 2015) https://www.sciencedirect.com/science/article/pii/S0379073815003564?via%3Dihub 
• New insights on the role of the endocannabinoid system in the regulation of energy balance. (France, abstract, 2015) https://pubmed.ncbi.nlm.nih.gov/26374449/ 
• Deletion of G-protein coupled receptor 55 promotes obesity by reducing physical activity. (USA/ China, abstract, 2015) https://www.semanticscholar.org/paper/Deletion-of-G-protein-coupled-receptor-55-promotes-Meadows-Lee/a372db59bc393f54339d909f71aff73fd0e75f51 
• Therapy with a Selective Cannabinoid Receptor Type 2 Agonist Limits Albuminuria and Renal Injury in Mice with Type 2 Diabetic Nephropathy. (Italy/ Switzerland/ Germany, abstract, 2015) https://www.karger.com/Article/Abstract/442679 
• G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis. (UK, abstract, 2015) https://link.springer.com/article/10.1007%2Fs00592-015-0826-9 
• The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease. (France, abstract, 2015) https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(15)00140-X                       
• 2014
• Novel drug target linked to insulin secretion and type 2 diabetes treatment (news–2014) http://medicalxpress.com/news/2014-05-drug-linked-insulin-secretion-diabetes.html
• 2013
• Marijuana: The next diabetes drug? (news–2013) http://www.cnn.com/2013/05/23/health/time-marijuana-diabetes/index.html
• Marijuana Users Have Better Blood Sugar Control (news–2013) http://www.sciencedaily.com/releases/2013/05/130515085208.htm
• Study: Why Pot Smokers Are Skinnier (news–2013) http://www.theatlantic.com/health/archive/2013/05/study-why-pot-smokers-are-skinnier/275846/
• Cannabis linked to prevention of diabetes (news–2013) http://www.independent.co.uk/life-style/health-and-families/health-news/cannabis-linked-to-prevention-ofdiabetes-8616314.html
• Cannabis-Derived Drug Shows Promise in Treating Type 2 Diabetes (news–2013) http://www.healthline.com/health-news/aging-cannabis-derived-drug-could-treat-type-2-diabetes-072313
• Marijuana Extract Holds Promise as Diabetes Treatment (news–2013) http://www.newsmax.com/Health-News/Type-2-diabetes-diabetes-drugs-marijuana-experimental-drugGWP42004/2013/07/19/id/516015
• Study: Marijuana Smokers Are Thinner And Healthier Than Non-Users (news–2013) http://www.opposingviews.com/i/society/study-marijuana-smokers-are-thinner-and-healthier-non-users
• 2012
• Study: Cannabis Use Associated With Decreased Prevailence Of Diabetes (news–2012) http://norml.org/news/2012/12/20/study-cannabis-use-associated-with-decreased-prevalence-of-diabetes
• Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is ‘Well Tolerated’ In Patients (news–2012) http://norml.org/news/2012/09/20/study-synthetic-thc-analogue-mitigates-diabetic-neuropathy-is-well-tolerated-in-patients
• Encouraging anti-diabetic results for new cannabinoid drug (news–2012) http://www.diabetes.co.uk/news/2012/Dec/encouraging-anti-diabetic-results-for-new-cannabinoid-drug-99996010.html
• New drug offers novel pain management therapy for diabetics (news-2012) http://www.thefreelibrary.com/New+drug+offers+novel+pain+management+therapy+for+diabetics.-a0306899453
• Drug offers new pain management therapy for diabetics (news–2012) http://medicalxpress.com/news/2012-10-drug-pain-therapy-diabetics.html
• 2011
• A Summary of Endocannabinoids and Obesity (news–2011) http://evolutionarypsychiatry.blogspot.com/2011/04/summary-of-endocannabinoids-and-obesity.html
• 2010
• Pot Compound Mitigates Diabetic Cardiomyopathy (news-2010) http://norml.org/news/2010/12/16/pot-compound-mitigates-diabetic-cardiomyopathy
• Cannabinoids inhibit and may prevent neuropathic pain in diabetes (news-2010) http://medigardens.blogspot.com/2010/04/march-2010-cannabinoids-inhibit-and-may.html
• Lab Notes: Pot Has Benefits for Diabetic Hearts (news-2010) http://www.medpagetoday.com/LabNotes/LabNotes/23853