MULTIPLE SCLEROSIS (MS)

MULTIPLE SCLEROSIS (MS):

• 2024
• Cannabidiol and neuro-degeneration: from molecular mechanisms to clinical benefits. https://www.sciencedirect.com/science/article/abs/pii/S1568163724002046
• Effectiveness, Safety and Patient's satisfaction of Nabiximols (sativex) on Multiple Sclerosis spasticity and related symptoms in a Swiss Multi-center study. https://pubmed.ncbi.nlm.nih.gov/38792448/ 
• Trends in prescription and cost of Sativex, a cannabinoid-based medicine, in treating patients with Multiple Sclerosis in England. https://pubmed.ncbi.nlm.nih.gov/38726319/ 
• Patient-reported benefits from Nabiximols treatment in Multiple Sclerosis-related spasticity exceed conventional measures. https://pubmed.ncbi.nlm.nih.gov/38318862/ 
• Clinical Outcome Analysis of patients with Multiple Sclerosis-analysis from the UK medical cannabis registry. https://www.sciencedirect.com/science/article/pii/S2211034824002426 
• Unveiling the potential of cannabinoids in Multiple Sclerosis and the dawn of nano-cannabinoid medicine. https://www.mdpi.com/1999-4923/16/2/241 
• 2023:
• Cannabis-Based Medicine for Neuropathic Pain and Spasticity- A multi-center, randomized, double-blinded, placebo-controlled trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459421/ 
• A post hoc evaluation of the shift in spasticity category in individuals with Multiple Sclerosis-related spasticity treated with Nabiximols. https://pubmed.ncbi.nlm.nih.gov/37745913/  
• Cannabinoids in Symptomatic treatment for people with multiple sclerosis: a systematic review of randomized studies. https://link.springer.com/article/10.1007/s40141-023-00416-4 
• Multiple sclerosis and use of Medical Cannabis: A retrospective review of a neurology outpatient population.  https://meridian.allenpress.com/ijmsc/article/25/3/111/489178/Multiple-Sclerosis-and-Use-of-Medical-Cannabis-A 
• Effectiveness and safety of Cannabinoids as an add-on therapy in the treatment of resistant spasticity in Multiple Sclerosis (MS): A Systematic Review. https://www.liebertpub.com/doi/10.1089/can.2022.0254 
• 2022:
• The cannabinoids and terpenes with anti-inflammatory potential: https://cannabishealthnews.co.uk/2022/11/22/cannabinoids-and-terpenes-anti-inflammatory-potential/
• 2021:
• Can Medical Marijuana Help Your MS? (news – 2015)
  https://www.webmd.com/multiple-sclerosis/multiple-sclerosis-medical-marijuana?src=RSS_PUBLIC#1
• (THC) and cannabidiol (CBD) oromucosal spray in resistant multiple sclerosis spasticity-consistency of response across subgroups from the SAVANT randomized clinical trial:  https://www.tandfonline.com/doi/abs/10.1080/00207454.2020.1730832
• 2020
• Dose-dependent effect of cannabinoid WIN-55,212-2 on myelin repair following a demyelinating insult. (Germany/ Spain/ Ghana, full, 2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969154/ 
• 2019
• An Update of Current Cannabis-Based Pharmaceuticals in Pain Medicine. (USA, full, 2019) https://link.springer.com/article/10.1007%2Fs40122-019-0114-4 
• Marijuana Use by Patients with Multiple Sclerosis. (USA, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489434/
• Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways. (USA, full, 2019) https://www.frontiersin.org/articles/10.3389/fimmu.2019.01921/full 
• The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia. (Spain/ Canada, full, 2019) https://www.sciencedirect.com/science/article/pii/S0889159118302411?via%3Dihub 
• Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders. (Netherlands, full, 2019) https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01405 
• Cannabis-based product use in a multiple sclerosis cohort. (Canada, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764052/ 
• Cannabinoids for the treatment of spasticity. (Australia, abstract in English, links to Portuguese & Spanish, 2019) https://pubmed.ncbi.nlm.nih.gov/30680713/ 
• Illegal cannabis use is common among Danes with multiple sclerosis. (Denmark, abstract, 2019) https://www.msard-journal.com/article/S2211-0348(19)30212-3/fulltext 
• Caring for people with multiple sclerosis who use cannabis for symptom control. (UK, abstract,  2019) https://pubmed.ncbi.nlm.nih.gov/31166770/ 
• Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome. (USA, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0889159119306476?via%3Dihub 
• Cannabinoid CB2 Receptor Functional Variation (Q63R) Is Associated with Multiple Sclerosis in Iranian Subjects. (Iran, abstract, 2019) https://www.semanticscholar.org/paper/Cannabinoid-CB2-Receptor-Functional-Variation-Is-in-Tahamtan-Rezaiy/0bd38a0c052e06c8ef7f40cfd5a89a009f8cd7b3 
• Exploring cannabis use by patients with multiple sclerosis in a state where cannabis is legal. (USA, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S2211034818305157 
• Combination of Imipramine, a sphingomyelinase inhibitor, and β-caryophyllene improve their therapeutic effects on experimental autoimmune encephalomyelitis (EAE). (Iran, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31711937/ 
• Safety, efficacy, and mechanisms of action of cannabinoids in neurological disorders. (USA/ Italy, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S1474442219300328 
• Dronabinol use in France between 2004 and 2017. (France, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0035378717308019 
• Pain Management in Multiple Sclerosis: a Review of Available Treatment Options. (USA, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31773455/ 
• Cannabinoids and the expanded endocannabinoid system in neurological disorders. (Italy/ Canada, abstract, 2019) https://www.nature.com/articles/s41582-019-0284-z 
• The Effects of Chronic Δ-9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) use on Cerebral Glucose Metabolism in Multiple Sclerosis: A Pilot Study. (USA, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31841355/ 
• Cannabis Use for Symptom Relief in Multiple Sclerosis: A Cross-Sectional Survey of Webinar Attendees in the US and Canada. (USA, abstract, 2019) https://www.msard-journal.com/article/S2211-0348(19)30837-5/fulltext 
• 2018
• Researchers Say Cannabis Can Benefit People with Multiple Sclerosis. (news – 2018)
  https://www.healthline.com/health-news/researchers-say-cannabis-can-benefit-people-with-multiple-sclerosis#1
• Cannabidiol to Improve Mobility in People with Multiple Sclerosis. (USA, full, 2018) https://www.frontiersin.org/articles/10.3389/fneur.2018.00183/full#B19
• The influence of THC:CBD oromucosal spray on driving ability in patients with multiple sclerosis‐related spasticity. (Norway/ Spain, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943754/ 
• Pain Modulation after Oromucosal Cannabinoid Spray (SATIVEX®) in Patients with Multiple Sclerosis: A Study with Quantitative Sensory Testing and Laser-Evoked Potentials. (Italy, full, 2018) https://www.mdpi.com/2305-6320/5/3/59/htm 
• Therapeutic potential of medicinal marijuana: an educational primer for health care professionals. (Canada, full, 2018) https://www.dovepress.com/therapeutic-potential-of-medicinal-marijuana-an-educational-primer-for-peer-reviewed-fulltext-article-DHPS 
• Ajulemic acid: potential treatment for chronic inflammation. (USA, full, 2018) https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.394 
• The Management of Lower Urinary Tract Dysfunction in Multiple Sclerosis. (UK, full, 2018) https://link.springer.com/article/10.1007%2Fs11910-018-0857-z 
• Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy. (Spain/ USA/ Italy/ Germany, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831753/ 
• Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the "weed," a pharmacodynamic discussion. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007535/ 
• An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. (Italy, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/ 
• Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells. (USA, full, 2018) https://www.frontiersin.org/articles/10.3389/fimmu.2018.01782/full 
• Traditional Uses of Cannabinoids and New Perspectives in the Treatment of Multiple Sclerosis. (Italy, full, 2018) https://www.mdpi.com/2305-6320/5/3/91/htm 
• Multiple Sclerosis, Cannabis Use, and Clinical Disability: A Preliminary [18F]- Fluorodeoxyglucose Positron Emission Tomography Study. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186162/ 
• Cannabis Therapeutics and the Future of Neurology. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200872/ 
• Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice. (Czech Republic, link to PDF, 2018) http://biomed.papers.upol.cz/artkey/bio-201801-0003_medical_cannabis_in_the_treatment_of_cancer_pain_and_spastic_conditions_and_options_of_drug_delivery_in_clinica.php
• Tetrahydrocannabinol/Cannabidiol Oromucosal Spray in Patients With Multiple Sclerosis: A Pilot Study on the Plasma Concentration-Effect Relationship. (Italy, link to PDF, 2018) https://www.researchgate.net/publication/326496634_TetrahydrocannabinolCannabidiol_Oromucosal_Spray_in_Patients_With_Multiple_Sclerosis_A_Pilot_Study_on_the_Plasma_Concentration-Effect_Relationship 
• Practical considerations in medical cannabis administration and dosing. (Canada/ Czech Republic, link to PDF, 2018) https://www.researchgate.net/publication/322257368_Practical_considerations_in_medical_cannabis_administration_and_dosing 
• The Use of Cannabis and Cannabinoids in Treating Symptoms of Multiple Sclerosis: a Systematic Review of Reviews. (Australia, abstract, 2018) https://link.springer.com/article/10.1007/s11910-018-0814-x 
• Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's disease and Less Well-Known Diseases. (Spain, Abstract, 2018) https://www.ingentaconnect.com/content/ben/cmc/2019/00000026/00000018/art00009 
• The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report. (USA, Abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0953620518300037 
• Cannabinoid therapy in practice. (Germany, abstract in German & English, 2018) https://link.springer.com/article/10.1007%2Fs00120-018-0636-0 
• The inhibition of CB1 receptor accelerates the onset and development of EAE possibly by regulating microglia/macrophages polarization. (China, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0165572817304678 
• Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis. (USA, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29512125/ 
• Clinical response to Nabiximols correlates with the down-regulation of immune pathways in Multiple Sclerosis. (Italy, abstract, 2018) https://www.semanticscholar.org/paper/Clinical-response-to-Nabiximols-correlates-with-the-Sorosina-Clarelli/47d74742e4fbfc8afe7be648f8d72f9e79853987 
• Cannabinoids for Treatment of MS Symptoms: State of the Evidence. (USA, abstract, 2018) https://link.springer.com/article/10.1007%2Fs11910-018-0859-x 
• Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination. (Spain/ USA, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0006295218303113 
• Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis. (Spain, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0006295218303630 
• Avidekel Cannabis extracts and cannabidiol are as efficient as Copaxone in suppressing EAE in SJL/J mice. (Israel, abstract, 2018) https://link.springer.com/article/10.1007/s10787-018-0536-3 
• β-Amyrin, the cannabinoid receptors agonist, abrogates mice brain microglial cells inflammation induced by lipopolysaccharide/interferon-γ and regulates Mφ1/Mφ2 balances. (Iran, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0753332217358201?via%3Dihub 
• 2017
• Massive scientific report on marijuana confirms medical benefits (news–2017) http://arstechnica.com/science/2017/01/massive-scientific-report-on-marijuana-confirms-medical-benefits/
• 5 Positive Takeaways From The Groundbreaking Health Report On Cannabis (news–2017) https://www.civilized.life/articles/the-latest-cannabis-health-report/
• Retired rabbi turned medical marijuana dispensary owner says Ohio laws will change: Q&A (news–2017) http://www.cleveland.com/metro/index.ssf/2017/03/thoughts_on_ohios_medical_mari.html
• Marijuana ‘saved my life’ (news–2017) http://www.wollondillyadvertiser.com.au/story/4678497/marijuana-saved-my-life/
• Cannabinoids May Treat Oxidative Stress-Related Neurodegenerative Disorders, Says New Study (news–2017) https://thejointblog.com/cannabinoids-may-treat-oxidative-stress-related-neurodegenerative-disorders-says-new-study/
• Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology? (Poland, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337874/ 
• Cannabis and cognitive functioning in multiple sclerosis: The role of gender. (Canada, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468765/ 
• Cannabis and Multiple Sclerosis—The Way Forward. (USA, full, 2017) https://www.frontiersin.org/articles/10.3389/fneur.2017.00299/full 
• Understanding Patients' Process to Use Medical Marijuana: A Southern New Jersey Community Engagement Project. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513646/ 
• Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid. (Israel, full, 2017) https://www.mdpi.com/1422-0067/18/8/1669/htm 
• Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS. (Canada, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433500/ 
• (-)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis. (Brazil, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412277/ 
• The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases. (Italy, full, 2017) https://www.sciencedirect.com/science/article/pii/S0301008217300709?via%3Dihub 
• Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation. (UK/ Iraq, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674070/ 
• Immunoregulatory Role of Cannabinoids during Infectious Disease. (Mexico, full, 2017) https://www.karger.com/Article/FullText/481824 
• Chapter 4 Neuropathic Pain in Multiple Sclerosis—Current Therapeutic Intervention and Future Treatment Perspectives. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/books/NBK470151/ 
• The role of Sativex in robotic rehabilitation in individuals with multiple sclerosis: Rationale, study design, and methodology. (Italy, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704890/ 
• 2-arachidonoylglycerol reduces proteoglycans and enhances remyelination in a progressive model of demyelination. (Spain/ Canada, full, 2017) https://www.jneurosci.org/content/37/35/8385.long 
• Cannabinoids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: a systematic review and meta-analysis. (Switzerland/ France/ UK, full, 2017) https://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.13759 
• Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9- Tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis. (Netherlands, full, 2017) https://www.clinicaltherapeutics.com/article/S0149-2918(17)30054-1/fulltext?rss=yes 
• Perspectives on marijuana use and effectiveness: A survey of NARCOMS participants. (USA/ Canada, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648201/ 
• Neuroprotection in oxidative stress-related neurodegenerative diseases: role of endocannabinoid system modulation. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984569/ 
• Cannabis use in people with Parkinson's disease and Multiple Sclerosis: A web-based investigation. (USA, link to PDF, 2017) https://www.researchgate.net/publication/318332922_Cannabis_use_in_people_with_Parkinson%27s_disease_and_Multiple_Sclerosis_A_web-based_investigation 
• Efficacy, tolerability and safety of cannabis-based medicines for chronic pain management - An overview of systematic reviews. (Germany/ Canada, abstract, 2017) https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1118 
• Systematic review of safeness and therapeutic efficacy of cannabis in patients with multiple sclerosis, neuropathic pain, and in oncological patients treated with chemotherapy. (Italy, abstract, 2017) http://www.epiprev.it/articolo_scientifico/revisione-sistematica-sull%E2%80%99efficacia-terapeutica-e-la-sicurezza-della-cannabis- 
• At the intersection of neurology and psychiatry : the impact of the differential diagnosis. (France, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/28653514/ 
• Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others? (Italy/ Spain/ Germany, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/28276775/ 
• TRPV1 polymorphisms and risk of interferon β-induced flu-like syndrome in patients with relapsing-remitting multiple sclerosis. (Italy, abstract, 2017) https://www.jni-journal.com/article/S0165-5728(16)30424-6/fulltext 
• The impact of cannabis and cannabinoids for medical conditions on health-related quality of life: A systematic review and meta-analysis. (USA, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0376871617300881 
• The effect of symptom-controlling medication on gait outcomes in people with multiple sclerosis: a systematic review. (Australia, abstract, 2017) https://www.semanticscholar.org/paper/The-effect-of-symptom-controlling-medication-on-in-Behm-Morgan/8b60e72bcf4aa94c3ea9e2540739b6f9fa54b134 
• Perspectives of Cannabinoid type 2 receptor (CB2R) ligands in neurodegenerative disorders: Structure Affinity Relationship (SAfiR) and Structure Activity Relationship (SAR) Studies. (Italy/ Albania, abstract, 2017) https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.7b00155 
• Sativex® effects on promoter methylation and on CNR1/CNR2 expression in peripheral blood mononuclear cells of progressive multiple sclerosis patients. (Italy, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0022510X17303921 
• Interferon-γ causes mood abnormalities by altering cannabinoid CB1 receptor function in the mouse striatum. (Italy, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0969996117301717?via%3Dihub 
• Managing neuropathic pain in multiple sclerosis: Pharmacological interventions. (Australia, abstract, 2017) https://www.eurekaselect.com/155364/article 
• Cannabinoids for spasticity due to multiple sclerosis or paraplegia: A systematic review and meta-analysis of randomized clinical trials. (Brazil/ Canada, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0965229917304466 
• THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study. (Italy, abstract, 2017) https://link.springer.com/article/10.1007/s10072-017-3148-6 
• Preserving the independence of people living with multiple sclerosis towards the end of life. (UK, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/29087751/ 
• Attitudes, perceptions, and use of marijuana in youth with multiple sclerosis. (USA, abstract, 2017) https://www.semanticscholar.org/paper/Attitudes%2C-perceptions%2C-and-use-of-marijuana-in-Brenton-Schreiner/44f4e1a9aadbff2353a056da7996a51edc376320   
• 2016
• Evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management of patients with spasticity due to multiple sclerosis. (Germany, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710104/ 
• Systematic Review of Pharmacological Properties of the Oligodendrocyte Lineage. (Italy, full, 2016) https://www.frontiersin.org/articles/10.3389/fncel.2016.00027/full
• THC:CBD Observational Study Data: Evolution of Resistant MS Spasticity and Associated Symptoms. (Italy, full, 2016) https://www.karger.com/Article/FullText/444235 
• THC:CBD in Daily Practice: Available Data from UK, Germany and Spain. (Spain, full, 2016) https://www.karger.com/Article/FullText/444234 
• Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. (Israel/ USA, full, 2016) https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0603-x 
• Efficacy and safety of cannabinoid oromucosal spray for multiple sclerosis spasticity. (Italy, full, 2016) https://jnnp.bmj.com/content/87/9/944.long
• Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis. (Italy/ Germany, full, 2016) https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0682-8 
• Potential Future Pharmacological Treatment of Bladder Dysfunction. (USA/ Denmark, full, 2016) https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12577 
• Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis. (Italy, full, 2016) https://academic.oup.com/painmedicine/article/17/6/1145/1752844 
• Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. (Spain/ USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321205/ 
• Development and Pharmacological Characterization of Selective Blockers of 2- Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. (Italy/ France/ USA, full, 2016) https://escholarship.org/uc/item/0nc4z28r 
• Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response. (Italy, link to PDF, 2016) https://www.researchgate.net/publication/304361367_Cannabinoids_and_Neuro-Inflammation_Regulation_of_Brain_Immune_Response 
• The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity. (Italy, link to download, 2016) https://www.semanticscholar.org/paper/The-effect-of-cannabinoids-on-the-stretch-reflex-in-Marinelli-Mori/5ac2d9162b74ff0c71df60ff4fffdc45b006f522?p2df 
• Cannabinoids and autoimmune diseases: A systematic review. (Israel, click “cedfoundation” for download, 2016) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22Cannabinoids+and+autoimmune+diseases%3A+A+systematic+review.%22&btnG 
• Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis. (Italy, Abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S0367326X16304476 
• Role of nurses in the managements of symptoms associated with spasticity in patients with multiple sclerosis. (Spain, abstract in English & Spanish, 2016) https://www.elsevier.es/es-revista-enfermeria-clinica-35-articulo-manejo-los-sintomas-asociados-espasticidad-S1130862116300882 
• Medical use of cannabis products : Lessons to be learned from Israel and Canada. (Germany, abstract in English & German, 2016) https://link.springer.com/article/10.1007/s00482-015-0083-4 
• A cost-effectiveness model for the use of a cannabis-derived oromucosal spray for the treatment of spasticity in multiple sclerosis. (UK, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/26750641/ 
• The emerging role of the cannabinoid receptor family in peripheral and neuro-immune interactions. (Ireland, abstract, 2016) https://www.eurekaselect.com/138448/article 
• Cannabinoids: Medical implications. (USA, abstract, 2016) https://www.semanticscholar.org/paper/Cannabinoids%3A-Medical-implications-Schrot-Hubbard/2aab2c83e7a45a160550cdad7a2c877e02b2c9cc 
• Toll-like receptor signalling as a cannabinoid target in Multiple Sclerosis. (Ireland, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S0028390816301459 
• MEDICAL CANNABIS. (Israel, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27215115/ 
• Influence of Previous Failed Antispasticity Therapy on the Efficacy and Tolerability of THC:CBD Oromucosal Spray for Multiple Sclerosis Spasticity. (Germany, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27160412/ 
• Refractory trigeminal neuralgia responsive to nabiximols in a patient with multiple sclerosis. (Italy, abstract, 2016) https://www.msard-journal.com/article/S2211-0348(16)30056-6/abstract 
• Modulation of monocytes by bioactive lipid anandamide in multiple sclerosis involves distinct Toll-like receptors. (Italy/ UK, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S1043661816309021 
• Cortical and spinal excitability in patients with multiple sclerosis and spasticity after oromucosal cannabinoid spray. (Italy, abstract, 2016) https://www.jns-journal.com/article/S0022-510X(16)30620-7/fulltext 
• Medical Cannabis - another piece in the mosaic of autoimmunity? (Israel, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27859024/ 
• Muscle elastography: a new imaging technique for multiple sclerosis spasticity measurement. (Italy, abstract, 2016) https://www.semanticscholar.org/paper/Muscle-elastography%3A-a-new-imaging-technique-for-Illomei-Spinicci/3caaf974bc120139c13f0c96b53db7f548285777 
• Attitudes to cannabis and patterns of use among Canadians with multiple sclerosis. (Canada, abstract, 2016) https://www.semanticscholar.org/paper/Attitudes-to-cannabis-and-patterns-of-use-among-Banwell-Pavisian/d6b1312f0d1dca1ed8eef6859683fb35e9145d41 
• Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. (Italy, abstract, 2016) https://www.jni-journal.com/article/S0165-5728(16)30274-0/fulltext#relatedArticles      
• 2015
• The entourage effect: Synergistic actions of plant cannabinoids (letter–2015) http://www.researchgate.net/publication/273330402_The_entourage_effect_Synergistic_actions_of_plant_cannabinoids
• What ailments does medical marijuana help? (news–2015) http://www.mnn.com/health/fitness-well-being/stories/what-ailments-does-medical-marijuana-help
• Huge New Review Shows What Medical Marijuana May (and May Not) Help (news–2015) https://www.yahoo.com/health/huge-new-review-shows-what-medical-marijuana-may-122209836947.html
• MS patients may someday find relief in marijuana chewing gum (news–2015) http://www.marketwatch.com/story/ms-patients-may-someday-find-relief-in-marijuana-chewing-gum-2015-08-17?siteid=rss&rss=1
• Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation. (Italy, full, 2015) https://www.hindawi.com/journals/np/2015/656582/ 
• Medicinal cannabis. (Australia, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674028/ 
• Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407719/ 
• Nabilone as an Adjunctive to Gabapentin for Multiple Sclerosis-Induced Neuropathic Pain: A Randomized Controlled Trial. (Canada, full, 2015) https://onlinelibrary.wiley.com/doi/full/10.1111/pme.12569 
• Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. (UK/ USA/ Romania, full, 2015) https://onlinelibrary.wiley.com/doi/full/10.1111/apha.12474 
• Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. (Israel/ USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363052/ 
• A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis. (Italy, full, 2015) https://link.springer.com/article/10.1186/s40199-015-0131-8 
• Narrative review of the safety and efficacy of marijuana for the treatment of commonly state-approved medical and psychiatric disorders. (USA, full, 2015) https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-015-0032-7 
• Activation of Cannabinoid CB2 receptors Reduces Hyperalgesia in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464808/ 
• The therapeutic potential of cannabinoids for movement disorders. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357541/ 
• Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe? (Iran/ UK, full, 2015) https://link.springer.com/article/10.1007/s13311-015-0367-5 
• A sativex-like combination of phytocannabinoids as a disease-modifying therapy in a viral model of multiple sclerosis. (Spain, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507161/ 
• Clinical perspectives on medical marijuana (cannabis) for neurologic disorders. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549715/ 
• Clinical Use of Cannabinoids for Symptom Control in Multiple Sclerosis. (UK, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604175/ 
• Sativex(®) and clinical-neurophysiological measures of spasticity in progressive multiple sclerosis. (Italy/ Spain, full, 2015) https://www.academia.edu/21225322/Sativex_and_clinical_neurophysiological_measures_of_spasticity_in_progressive_multiple_sclerosis 
• Purified Cannabidiol, the main non-psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis. (Italy, link to PDF, 2015) https://www.europeanreview.org/article/10049 
• Drug-resistant MS spasticity treatment with Sativex® add-on and driving ability. (Germany, link to PDF, 2015) https://www.researchgate.net/publication/265556600_Drug-resistant_MS_spasticity_treatment_with_SativexR_add-on_and_driving_ability 
• Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids. (UK, link to PDF, 2015) https://www.researchgate.net/publication/270004494_Neuroprotection_in_Experimental_Autoimmune_Encephalomyelitis_and_Progressive_Multiple_Sclerosis_by_Cannabis-Based_Cannabinoids 
• Walking improvements with nabiximols in patients with multiple sclerosis. (Italy, link to PDF, 2015) https://www.researchgate.net/publication/280644357_Walking_improvements_with_nabiximols_in_patients_with_multiple_sclerosis 
• HU-446 and HU-465, derivatives of the non-psychoactive cannabinoid cannabidiol, decrease the activation of encephalitogenic T cells. (Israel/ India, link to download, 2015) https://www.academia.edu/21241976/HU_446_and_HU_465_derivatives_of_the_non_psychoactive_cannabinoid_cannabidiol_decrease_the_activation_of_encephalitogenic_T_cells 
• Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. (Iran, link to download, 2015) https://www.semanticscholar.org/paper/Alteration-of-delta-6-desaturase-%28FADS2%29%2C-secretory-Rezapour-Firouzi-Arefhosseini/010f0b614ca6a40237614269a36d2c4ac1626862?p2df 
• Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice. (Iran, Abstract, 2015) https://realmofcaring.org/research/interaction-between-the-protective-effects-of-cannabidiol-and-palmitoylethanolamide-in-experimental-model-of-multiple-sclerosis-in-c57bl6-mice/ 
• New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity. (Italy/ Finland, abstract, 2015) https://www.sciencedirect.com/science/article/abs/pii/S0223523415002937 
• Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis. (Germany, abstract, 2015) https://www.tandfonline.com/doi/abs/10.1586/14737175.2015.1067607 
• Endocannabinoids in Multiple Sclerosis and Amyotrophic Lateral Sclerosis. (UK, abstract, 2015) https://link.springer.com/chapter/10.1007%2F978-3-319-20825-1_7 
• Use of Cannabinoids for Spasticity and Pain Management in MS. (USA, abstract, 2015) https://link.springer.com/article/10.1007%2Fs11940-015-0385-y 
• Effectiveness and Tolerability of THC/CBD Oromucosal Spray for Multiple Sclerosis Spasticity in Italy: First Data from a Large Observational Study. (Italy, abstract, 2015) https://pubmed.ncbi.nlm.nih.gov/26571097/ 
• Efficacy and safety of nabiximols (Sativex®) on multiple sclerosis spasticity in a real-life Italian monocentric study. (Italy, abstract, 2015) https://www.semanticscholar.org/paper/Efficacy-and-safety-of-nabiximols-(Sativex%C2%AE)-on-in-Ferre-Nuara/3de44eca12cb1f92457e31f6cb0f794056b13763    
• 2014
• Report On Medical Cannabis Research, What the Science Says (article–2014) http://www.safeaccessnow.org/medical_cannabis_research_what_does_the_evidence_say
• Study uncovers marijuana’s potential to treat autoimmune diseases (news–2014) http://www.news-medical.net/news/20140603/Study-uncovers-marijuanas-potential-to-treat-autoimmune-diseases.aspx
• 2013
• Adequate and Well-Controlled Studies Proving Medical Efficacy of Cannabis Exist but Are Ignored by Marijuana Schedulers (news–2013) http://www.huffingtonpost.com/sunil-kumar-aggarwal/marijuana-schedule-1_b_3071725.html
• Still Believe Nature Got It Wrong? Top 10 Health Benefits of Marijuana (news–2013) http://www.wakingtimes.com/2013/05/01/still-believe-nature-got-it-wrong-top-10-health-benefits-of-marijuana/
• Research shows marijuana can be effectively used to treat multiple sclerosis (news–2013) http://www.naturalnews.com/042498_marijuana_multiple_sclerosis_natural_treatment.html
• Medical Marijuana: Consortium of Multiple Sclerosis Centers (news–2013) http://www.msviews.org/msviewsandnews4/index.php/2012%C2%A0-05-28-00-15-54/2012-07-04-00-19-28/610-medical-marajuana-consortium-of-multiple-sclerosis-centers
• Aylsham multiple sclerosis sufferer says cannabis-based drug ‘changed my life’ (news-2013) http://www.eveningnews24.co.uk/news/aylsham_multiple_sclerosis_sufferer_says_cannabis_based_drug_changed_my_life_1_2276182
• Multiple Sclerosis and Cannabis – A Conversation With Clark French (news–2013) http://www.huffingtonpost.co.uk/jason-reed/multiple-sclerosis-and-cannabis_b_1902151.html
• Sending multiple sclerosis up in smoke (news–2013) http://www.eurekalert.org/pub_releases/2013-10/afot-sms100713.php
• Chemicals in marijuana ‘protect nervous system’ against MS (news–2013) http://www.medicalnewstoday.com/articles/267161.php
• 2012
• Marijuana Pill Relieves MS and RSD/CRPS Symptoms Plus Pain (news–2012) http://www.rsdinfocenter.com/blog/2012/10/marijuana-pill-relieves-ms-and-rsdcrps-symptoms-plus-pain/
• Cannabis-based medications prove effective in relieving pain (news–2012) http://www.news-medical.net/news/20120807/Cannabis-based-medications-prove-effective-in-relieving-pain.aspx
• Cannabis Effective for Easing MS Symptoms, but Not for Slowing Progression (news–2012) http://www.prweb.com/releases/-medical-marijuana/-information-san-francisc/prweb9568927.htm
• Study: Smoking pot may ease pain, muscle spasms in people with multiple sclerosis (news–2012) http://www.cbsnews.com/news/study-smoking-pot-may-ease-pain-muscle-spasms-in-people-with-multiple-sclerosis/
• 2010
• Nature’s (Legal) Cannabinoids (news-2010) http://www.mapinc.org/drugnews/v10/n126/a04.html?1194
• Marijuana and MS–an unfinished story (news-2010) http://www.thefreelibrary.com/Marijuana+and+MS–an+unfinished+story.-a0237205183