AMYOTROPHIC LATERAL SCLEROSIS/LOU GERHIG’S DISEASE (ALS)

AMYOTROPHIC LATERAL SCLEROSIS/LOU GERHIG’S DISEASE (ALS): 

• 2024:
• Cannabidiol and neuro-degeneration: from molecular mechanisms to clinical benefits. https://www.sciencedirect.com/science/article/abs/pii/S1568163724002046
• 2020
• Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission? (Italy/ Netherlands, full, 2020) https://www.mdpi.com/1422-0067/21/3/723/htm 
• 2019
• What Can Cannabis Do for Patients with ALS? (news–2019)  https://news.weedmaps.com/2019/07/what-can-cannabis-do-for-patients-with-als/
• Cannabis Hyperemesis Syndrome in Palliative Care: A Case Study and Narrative Review. (USA, click “dalgarnoinstitute” for download, 2019) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Cannabis+Hyperemesis+Syndrome+in+Palliative+Care%3A+A+Case+Study+and+Narrative+Review.&btnG 
• Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol. (Italy, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915685/ 
• Cannabinoids and the expanded endocannabinoid system in neurological disorders. (Italy/ Canada, abstract, 2019) https://www.nature.com/articles/s41582-019-0284-z 
• 2018
• An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. (Italy, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/  
• Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system. (Spain, click “open access” then “Dipositubedu” for download, 2018) https://www.semanticscholar.org/paper/Cannabinoid-pharmacology%2Ftherapeutics-in-chronic-Aymerich-As%C3%B3/2e9946a36f70b0f5e320459b0f8f7a7125c72bdc 
• Analysis of endocannabinoid receptors and enzymes in the post-mortem motor cortex and spinal cord of amyotrophic lateral sclerosis patients. (Spain, abstract, 2018) https://www.tandfonline.com/doi/full/10.1080/21678421.2018.1425454 
• Evaluation of 4-oxo-quinoline-based CB2 PET radioligands in R6/2 chorea huntington mouse model and human ALS spinal cord tissue. (Switzerland, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0223523417311285?via%3Dihub 
• Targeting glial CB2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis. (Spain, abstract, 2018) https://www.semanticscholar.org/paper/Targeting-glial-cannabinoid-CB2-receptors-to-delay-Espejo-Porras-Garc%C3%ADa-Toscano/4e20464e4caa67a7fff52abbcbe14be8dff959da 
• Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis. (Spain, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0006295218303198  
• 2017
• Essential Dietary Bioactive Lipids in Neuroinflammatory Diseases. (Italy, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984567/ 
• Up-regulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis. (Spain/ USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451172/ 
• Neurological aspects of medical use of cannabidiol. (Italy, click “coreacuk” for download, 2017) https://scholar.google.com/scholar?q=%22Neurological+Aspects+of+Medical+Use+of+Cannabidiol%22&hl=en&as_sdt=0&as_vis=1&oi=scholart 
• Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS. (Germany, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0028390817301296?via%3Dihub 
• 2016
• Marijuana May Treat ALS and Improve Survival Rate (news–2016)  https://www.marijuanatimes.org/marijuana-may-treat-als-and-improve-survival-rate/
• Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. (Spain/ USA, full, 2016) https://www.frontiersin.org/articles/10.3389/fnins.2016.00406/full 
• Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy. (Italy/ USA/ Mexico, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801305/ 
• Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis? (Italy, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270417/ 
• Pros and cons of medical cannabis use by people with chronic brain disorders. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652027/ 
• Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response. (Italy, link to PDF, 2016) https://www.researchgate.net/publication/304361367_Cannabinoids_and_Neuro-Inflammation_Regulation_of_Brain_Immune_Response 
• Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked with Amyotrophic Lateral Sclerosis. (USA, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27714895/ 
• Pain in amyotrophic lateral sclerosis. (Italy, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27964824/        
• 2015
• Narrative review of the safety and efficacy of marijuana for the treatment of commonly state-approved medical and psychiatric disorders. (USA, full, 2015) https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-015-0032-7 
• Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications. (Spain, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604192/ 
• Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders. (Spain/ Italy, abstract, 2015) https://link.springer.com/article/10.1007%2Fs11481-015-9602-4 
• Endocannabinoids in Multiple Sclerosis and Amyotrophic Lateral Sclerosis. (UK, abstract, 2015) https://link.springer.com/chapter/10.1007%2F978-3-319-20825-1_7 
• 2014
• Cannabis Science: Finding The Optimal Therapeutic Ratio Of THC And CBD (news–2014) http://www.medicaljane.com/2014/05/29/finding-the-optimal-therapeutic-ratio-of-thc-and-cbd/#
• Treating Amyotrophic Lateral Sclerosis (ALS) Symptoms with Medical Marijuana (news–2014) https://www.medicaljane.com/2014/11/12/amyotrophic-lateral-sclerosis-als-and-medical-marijuana/
• 2010
• Marijuana May Extend Life Expectancy Of Lou Gehrig’s Disease Patients, Study Says (news-2010) http://blog.norml.org/2010/05/19/marijuana-may-extend-life-expectancy-of-lou-gehrig%E2%80%99s-disease-patients-study-says/
• Cannabis and Lou Gehrig’s Disease (news–2010)  http://www.amarimed.com/DOCBLOG/tabid/90/EntryId/12/Cannabis-and-Lou-Gehrigs-Disease.aspx
• Undated
• ALS and Medical Marijuana (news-undated) http://www.floridamarijuanainfo.org/als-and-medical-marijuana/