ARTHRITIS

ARTHRITIS:

• 2024
• Effect of topical hemp seed oil on knee osteoarthritis: a randomized double-blind controlled trial. https://www.sciencedirect.com/science/article/abs/pii/S1524904224002297 
• Substituting Medical Cannabis for Medications Among Patients With Rheumatic Conditions in the United States and Canada. https://pubmed.ncbi.nlm.nih.gov/39236308/ 
• Assessment of Clinical outcomes in patients with inflammatory arthritis: Analysis from the UK medical cannabis registry. https://journals.lww.com/intclinpsychopharm/fulltext/9900/assessment_of_clinical_outcomes_in_patients_with.145.aspx 
• An open-label feasibility trial of transdermal cannabidiol for hand osteoarthritis. https://pubmed.ncbi.nlm.nih.gov/38783008/ 
• Assessment of Clinical outcomes in patients with osteoarthritis: Analysis from the UK Medical Cannabis Registry. https://pubmed.ncbi.nlm.nih.gov/38669060/ 
• 2023
• Effects of Cannabidiol (CBD) on the inflammatory response of patients with Rheumatoid Arthritis. https://ipipublishing.org/index.php/emjsr/article/view/14 
• 2022:
• Medicinal Cannabis for Australian patients with chronic refractory pain including arthritis. https://journals.sagepub.com/doi/10.1177/20494637221147115 
• Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study (Frane, et al, 2022) https://pubmed.ncbi.nlm.nih.gov/35999581/ 
• The cannabinoids and terpenes with anti-inflammatory potential:https://cannabishealthnews.co.uk/2022/11/22/cannabinoids-and-terpenes-anti-inflammatory-potential/
• Cannabis and Cannabinoids in the Treatment of Rheumatic Diseases:  https://www.ncbi.nlm.nih.gov/pubmed/32017684?dopt=Abstract
• Aging & Medical Marijuana. (USA, booklet, undated) https://www.safeaccessnow.org/aging 
• 2020
• Cannabis and Cannabinoids in the Treatment of Rheumatic Diseases. (Israel, link to download, 2020) https://www.rmmj.org.il/userimages/1006/1/PublishFiles/1025Article.pdf 
• Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis. (Canada, full, 2020) https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-2096-3 
• Cannabinoids CB2 Receptors, One New Promising Drug Target for Chronic and Degenerative Pain Conditions in Equine Veterinary Patients. (Mexico, abstract, 2020) https://pubmed.ncbi.nlm.nih.gov/31952645/ 
• 2019
• Lesotho cashes in on medicinal cannabis boom as British firm opens CBD factory  (news–2019) https://www.yahoo.com/news/lesotho-cashes-medicinal-cannabis-boom-173448548.html
• Marijuana Topical Cream to Relieve Arthritis Pain (news–2019)
  https://www.cannadish.net/marijuana-topical-cream-to-relieve-arthritis-pain/
• What Every Person With Arthritis Needs to Know About Cannabis (news–2019)
  https://www.healthcentral.com/article/laws-for-cannabis-and-arthritis
• Patterns of Marijuana Use and Health Impact: A Survey Among Older Coloradans. (USA, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487769/ 
• Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor. (USA, full, 2019) https://www.frontiersin.org/articles/10.3389/fimmu.2019.01027/full 
• β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors. (Italy, full, 2019) https://www.mdpi.com/2218-273X/9/8/326/htm 
• Cannabis for musculoskeletal pain and arthritis: Evidence is needed. (France, full for purchase, 2019) https://www.sciencedirect.com/science/article/pii/S1297319X18300472 
• A National Survey of Marijuana Use Among US Adults With Medical Conditions, 2016- 2017. (USA, full, 2019) https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2751558 
• Metabolic syndrome and osteoarthritis pain: common molecular mechanisms and potential therapeutic implications. (UK, full, 2019) https://www.oarsijournal.com/article/S1063-4584(19)31154-9/fulltext 
• The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases. (Italy, full, 2019) https://www.mdpi.com/1422-0067/20/23/5875/htm 
• Position Statement: A Pragmatic Approach for Medical Cannabis and Patients with Rheumatic Diseases. (Germany/ Canada, link to PDF, 2019) https://www.researchgate.net/publication/330405468_Position_Statement_A_Pragmatic_Approach_for_Medical_Cannabis_and_Patients_with_Rheumatic_Diseases 
• Cannabis for pain in orthopedics: a systematic review focusing on study methodology. (Canada/ Netherlands / Spain, link to PDF, full in English & abstract in French, 2019) http://canjsurg.ca/62-6-001018/ 
• Joints for joints: cannabinoids in the treatment of rheumatoid arthritis. (Germany, click “shayahealth” for download, 2019) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22Joints+for+joints%3A+cannabinoids+in+the+treatment+of+rheumatoid+arthritis.%22&btnG 
• Patient preferences for rheumatoid arthritis treatment. (USA, abstract, 2019) https://journals.lww.com/co-rheumatology/Abstract/2019/05000/Patient_preferences_for_rheumatoid_arthritis.7.aspx 
• Medical cannabis and cannabinoids in rheumatology: where are we now? (Italy/ Germany/ Israel, click “researchgate” for download, 2019) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22Medical+cannabis+and+cannabinoids+in+rheumatology%3A+where+are+we+now%3F++%22&btnG 
• 2018
• Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis. (Poland, full, 2018) https://www.mdpi.com/1422-0067/19/2/342/htm 
• Electroacupuncture Potentiates Cannabinoid Receptor-Mediated Descending Inhibitory Control in a Mouse Model of Knee Osteoarthritis. (China / USA, full, 2018) https://www.frontiersin.org/articles/10.3389/fnmol.2018.00112/full 
• Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. (Canada/ USA, full, 2018) https://link.springer.com/article/10.1186/s10194-018-0862-2 
• Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients. (Poland/ Croatia, full, 2018) https://www.mdpi.com/2073-4409/7/10/159/htm 
• Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation. (China, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882028/ 
• Endogenous systems involved in exercise-induced analgesia. (Brazil, full, 2018) http://www.jpp.krakow.pl/journal/archive/02_18/articles/01_article.html 
• Ajulemic acid: potential treatment for chronic inflammation. (USA, full, 2018) https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.394 
• Joint problems arising from lack of repair mechanisms: can cannabinoids help? (Poland, abstract, 2018) https://www.semanticscholar.org/paper/Joint-problems-arising-from-lack-of-repair-can-help-Ma%C5%82ek-Starowicz/86b492b8ed45c96661af17edd1cdd337f994c355 
• Cannabis and joints: scientific evidence for the alleviation of osteoarthritis pain by cannabinoids. (Canada, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S1471489218300043?via%3Dihub 
• Genetic Variant Q63R of Cannabinoid Receptor 2 (CB2R) Causes Differential ERK Phosphorylation in Human Immune Cells. (China, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29694791/ 
• Cannabinoids for the treatment of rheumatic diseases - where do we stand? (Israel, abstract, 2018) https://www.semanticscholar.org/paper/Cannabinoids-for-the-treatment-of-rheumatic-%E2%80%94-where-Katz-Talmor-Katz/396ec0b6a979675d276cea25f17e850ff5d0542f 
• Study of cannabinoid receptor 2 Q63R gene polymorphism in Lebanese patients with rheumatoid arthritis. (Lebanon, abstract, 2018) https://link.springer.com/article/10.1007/s10067-018-4217-9 
• Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis. (Spain, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0006295218303630 
• 2017
• Should I prescribe marijuana for my patients? Senior users weigh in (news–2017) http://www.jweekly.com/2017/06/18/should-i-prescribe-marijuana-for-my-patients-senior-users-weigh-in/
• Take two hits of Maui Wowie and call me in the morning: Baby boomers in the age of medical marijuana (news–2017) http://www.bridgemi.com/quality-life/take-two-hits-maui-wowie-and-call-me-morning-baby-boomers-age-medical-marijuana
• Cannabis Topicals: Creams, Salves and Lotions. Why Seniors are Thriving (news/ad–2017) https://unitedpatientsgroup.com/blog/2017/04/20/Cannabis-Topicals-Creams-Salves-and-Lotions-Why-Seniors-are-Thriving
• Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice. (Canada, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445456/ 
• Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis. (Poland, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573042/ 
• Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain. (Canada/ USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628559/ 
• Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study. (Italy, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674828/ 
• The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease. (Australia, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685274/ 
• Cannabidiol as a Therapy for ASIA Syndrome? An Editorial on a Novel Study. (Israel, link to PDF, 2017) https://www.ima.org.il/MedicineIMAJ/viewarticle.aspx?aid=4046 
• Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withania somnifera compounds elucidating the medicinal properties against rheumatoid arthritis. (Pakistan/ China, click “iozaccn” for download, 2017) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22Comparative+in+silico+analyses+of+Cannabis+sativa%2C+Prunella+vulgaris+and+Withania+%09somnifera+compounds+elucidating+the+medicinal+properties+against+rheumatoid+arthritis.&btnG 
• Endocannabinoids in arthritis: current views and perspective. (Australia, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/28736968/ 
• In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor. (Japan, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/29017758/ 
• 2016
• Raid! National Guard, State Police descend on 81-year-old’s property to seize single pot plant (news–2016) http://www.gazettenet.com/MarijuanaRaid-HG-100116-5074664
• Pet owners try cannabis edibles, tinctures to ease animal anxiety, arthritis and more (news–2016) http://www.thecannifornian.com/cannabis-health/pet-owners-try-edibles-ease-anxiety-arthritis/
• Even in legal weed states, parents who consume pot can still lose custody of their kids (news–2016) http://www.thecannifornian.com/cannabis-news/california-news/parents-facing-custody-issues-marijuana-see-hope-prop-64/
• Using Cannabis to Combat Arthritis (news–2016) https://www.marijuanatimes.org/using-cannabis-to-combat-arthritis/
• Illegal Patient Profiles: Spending the Golden Years with Cannabis (news–2016) https://www.marijuanatimes.org/illegal-patient-profiles-spending-the-golden-years-with-cannabis/
• Attitudes of Israeli Rheumatologists to the Use of Medical Cannabis as Therapy for Rheumatic Disorders. (Israel/ Canada, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839539/ 
• The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets. (Germany, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858820/ 
• The CB2 receptor and its role as a regulator of inflammation. (Canada, full, 2016) https://link.springer.com/article/10.1007/s00018-016-2300-4 
• Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719019/ 
• Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1. (China, full, 2016) https://www.spandidos-publications.com/10.3892/mmr.2016.5137 
• Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain. (UK/ USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056226/ 
• Cannabinoids in the Management of Musculoskeletal or Rheumatic Diseases. (Canada/ Germany, link to PDF, 2016) https://www.researchgate.net/publication/309881162_Cannabinoids_in_the_Management_of_Musculoskeletal_or_Rheumatic_Diseases 
• Cannabinoids and autoimmune diseases: A systematic review. (Israel, click “cedfoundation” for download, 2016) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22Cannabinoids+and+autoimmune+diseases%3A+A+systematic+review.%22&btnG 
• MEDICAL CANNABIS. (Israel, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27215115/ 
• Endocannabinoids inhibit neurogenic inflammation in murine joints by a non-canonical cannabinoid receptor mechanism. (Canada, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S0143417916300476 
• Survey of herbal cannabis (marijuana) use in rheumatology clinic attenders with a rheumatologist confirmed diagnosis. (Canada, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27842047/ 
• Medical Cannabis - another piece in the mosaic of autoimmunity? (Israel, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27859024/ 
• 2015
• Study: Cannabinoid Use in the Treatment of Osteoarthritis Pain (news-2015) http://www.medicaljane.com/2015/01/26/cannabinoid-use-in-the-treatment-of-osteoarthritis-pain/
• Dalhousie researcher investigates use of marijuana for arthritis pain (news-2015) http://www.cbc.ca/news/canada/nova-scotia/dalhousie-researcher-investigates-use-of-marijuana-forarthritis-pain-1.3142592?cmp=rss
• What ailments does medical marijuana help? (news-2015) http://www.mnn.com/health/fitness-well-being/stories/what-ailments-does-medical-marijuana-help
• 10 diseases where medical marijuana could have impact (news-2015) http://www.cnn.com/2015/04/15/health/marijuana-medical-advances/index.html
• Family seeking cannabinoid spray prescription say many more could benefit (news–2015) http://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=11490218&ref=rss
• Why Doris, 73, puts cannabis in her sandwiches (news–2015) http://www.leighobserver.co.uk/news/north-west-news/why-doris-73-puts-cannabis-in-her-sandwiches-1-7392194
• Many Teens With Chronic Illnesses Use Alcohol, Pot (news–2015) http://www.medicinenet.com/script/main/art.asp?articlekey=190363
• Cannabinoid Receptor CB2 Is Involved in Tetrahydrocannabinol-Induced AntiInflammation against Lipopolysaccharide in MG-63 Cells. (China, full, 2015) https://www.hindawi.com/journals/mi/2015/362126/ 
• Leptin Levels Are Negatively Correlated with 2-Arachidonoylglycerol in the Cerebrospinal Fluid of Patients with Osteoarthritis. (USA/ Sweden/ Italy, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383333/ 
• Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. (Germany, full, 2015) https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-015-0743-x 
• Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner. (Germany, full, 2015) https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-015-0845-5 
• Endocannabinoids and acute pain after total knee arthroplasty. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299927/ 
• Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. (Spain, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770330/ 
• Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/ 
• Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis. (France, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935402/ 
• The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice. (UK, full, 2015) https://www.oarsijournal.com/article/S1063-4584(15)01140-1/fulltext 
• Efficacy, tolerability and safety of cannabinoid treatments in the rheumatic diseases: A systematic review of randomized controlled trials. (Canada/ Germany/ USA, full, 2015) https://onlinelibrary.wiley.com/doi/full/10.1002/acr.22727 
• HU-444, A Novel, Potent Anti-Inflammatory, Non-Psychotropic Cannabinoid. (Israel/ UK, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576666/ 
• Association between cannabinoid receptor type 2 Q63R variant and oligo/polyarticular juvenile idiopathic arthritis. (Italy, link to PDF, 2015) https://www.researchgate.net/publication/276358940_Association_between_cannabinoid_receptor_type_2_Q63R_variant_and_oligopolyarticular_juvenile_idiopathic_arthritis 
• A multi-target approach for pain treatment - dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. (Poland/ Italy, click “academia” for download, 2015) https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22A+multi-target+approach+for+pain+treatment%22&btnG 
• The endocannabinoid system and its therapeutic implications in rheumatoid arthritis. (China/ USA, link to download, 2015) https://www.semanticscholar.org/paper/Therapeutic-implications-of-the-endocannabinoid-in-Zogopoulos-Vretakos/269a7d604206a8f49e0ab57d69940238d66ab210?p2df 
• The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review. (Sweden, partial preview, 2015) https://books.google.com/books?hl=en&lr=&id=QwihCgAAQBAJ&oi=fnd&pg=PA94&ots=FMMqCCFXmD&sig=Lj-60GdDPoB2MXCwwn6xyfuuDv0#v=onepage&q&f=false 
• Activation of cannabinoid receptor 2 attenuates synovitis and joint distruction in collagen-induced arthritis. (China, abstract, 2015) https://www.sciencedirect.com/science/article/abs/pii/S0171298514002812 
• 2014
• Drugs Related to Cannabis Have Pain-Relieving Potential for Osteoarthritis (news–2014) http://www.sciencedaily.com/releases/2014/01/140107092825.htm
• Cannabis May Offer Relief for Connective Tissue Disorders (news–2014) http://theleafonline.com/c/science/2014/05/cannabis-may-offer-relief-for-connective-tissue-disorders/
• Protection from osteoarthritis may lie in our own joints, study suggests (news-2014) https://www.sciencedaily.com/releases/2014/05/140518092722.htm
• Could Cannabis Treat Rheumatoid Arthritis? New Study Says It May (news-2014) http://www.theweedblog.com/could-cannabis-treat-rheumatoid-arthritis-new-study-says-it-may/
• 2012
• Neuromodulators for pain management in rheumatoid arthritis (abst/summary – 2012) http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008921.pub2/abstract
• Reefer tokin’ seniors in South Florida see pain go up in smoke (news–2012) http://articles.sun-sentinel.com/2012-07-23/news/fl-toking-oldsters-20120723_1_reefer-pain-seniors
• Can medical marijuana help rheumatoid arthritis? (news–2012) http://www.health.com/health/condition-article/0,,20499017,00.html
• 2011
• Medical Marijuana For Rheumatoid Arthritis? (news–2011)  http://www.huffingtonpost.com/2011/06/08/can-medical-marijuana-help-arthritis_n_873189.html
• Benefits From Medical Marijuana (news–2011)  http://www.livestrong.com/article/98476-medical-reasons-marijuana/