BLOOD-BRAIN BARRIER

BLOOD-BRAIN BARRIER:

• 2019
• CBD’s Role in Beating Deadly Disease Uncovered in Blood-Brain Barrier Study  (news/abst–2019) https://www.inverse.com/article/55030-cbd-could-help-deliver-chemotherapy-drugs
• CBDs Help Medication Cross the Blood Brain Barrier. (news – 2019)
  https://www.labroots.com/trending/cannabis-sciences/14554/cbds-help-medication-cross-blood-brain-barrier
• Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome. (Israel, full, 2019) https://www.mdpi.com/2072-6651/11/5/275/htm 
• Fatty acids and selected endocannabinoids content in cerebrospinal fluids from patients with neuroinfections. (Poland/ USA, full, 2019) https://link.springer.com/article/10.1007%2Fs11011-018-0347-7 
• Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders. (Netherlands, full, 2019) https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01405
• Stearoylethanolamide interferes with retrograde endocannabinoid signalling and supports the blood-brain barrier integrity under acute systemic inflammation. (Ukraine/ Austria/ Germany, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0006295219304824?via%3Dihub 
• 2018
• Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury. (USA, full, 2018) https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1166-9 
• Cannabinoid receptor 2 agonist attenuates blood-brain barrier damage in a rat model of intracerebral hemorrhage by activating the Rac1 pathway. (China, link to PDF, 2018) https://www.semanticscholar.org/paper/Cannabinoid-receptor-2-agonist-attenuates-barrier-a-Wang-Li/35e04419072cffd25ed128e3c8d0f3382c348543 
• A cannabinoid receptor 2 agonist reduces blood-brain barrier damage via induction of MKP-1 after intracerebral hemorrhage in rats. (China, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0006899318303330?via%3Dihub 
• 2017
• How THC Gets Into Your Brain – And How To Increase It. (news – 2017)
  http://profofpot.com/thc-blood-brain-barrier/
• Endocannabinoids: A Promising Impact for Traumatic Brain Injury. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314139/ 
• The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases. (Italy, full, 2017) https://www.sciencedirect.com/science/article/pii/S0301008217300709?via%3Dihub 
• Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice. (China, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740744/ 
• Essential Dietary Bioactive Lipids in Neuroinflammatory Diseases. (Italy, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984567/ 
• Targeting fatty-acid amide hydrolase with prodrugs for CNS-selective therapy. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342467/ 
• Chapter Eleven - Is the Cannabinoid CB2 Receptor a Major Regulator of the Neuroinflammatory Axis of the Neurovascular Unit in Humans? (New Zealand, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S1054358917300376?via%3Dihub 
• Re-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases. (USA, abstract, 2017) https://link.springer.com/article/10.1007/s11892-017-0924-x 
• Remote Ischemia Preconditioning Attenuates Blood-Spinal Cord Barrier Breakdown in Rats Undergoing Spinal Cord Ischemia Reperfusion Injury: Associated with Activation and Upregulation of CB1 and CB2 Receptors. (China, full, 2017) https://www.karger.com/Article/FullText/484460 
• 2016
• Temple researchers to explore ability of compounds to protect brain against HIV infection (news–2016) http://www.eurekalert.org/pub_releases/2016-03/tuhs-trt032816.php
• Human Metabolism of THC. (news – 2016)
  https://sapiensoup.com/human-metabolism-thc
• ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice. (Australia, full, 2016) https://peerj.com/articles/2081/ 
• Endocannabinoids and Heterogeneity of Glial Cells in Brain Function. (Germany, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932105/ 
• Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17-dependent mechanism. (Germany/ Switzerland, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016688/ 
• Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. (Spain/ USA, full, 2016) https://www.frontiersin.org/articles/10.3389/fnins.2016.00406/full 
• CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease. (Republic of Korea, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892852/ 
• Peripherally selective cannabinoid 1 receptor (CB1R) agonists for the treatment of neuropathic pain. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474949/ 
• ENDOCANNABINOID SYSTEM: A multi-facet therapeutic target. (India, link to PDF, 2016) https://www.researchgate.net/publication/301533431_Endocannabinoid_System_A_Multi-Facet_Therapeutic_Target 
• Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response. (Italy, link to PDF, 2016) https://www.researchgate.net/publication/304361367_Cannabinoids_and_Neuro-Inflammation_Regulation_of_Brain_Immune_Response    
• The molecular mechanism and effect of cannabinoid-2 receptor agonist on the bloodspinal cord barrier permeability induced by ischemia-reperfusion injury. (China, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S0006899316300245?via%3Dihub 
• 2015
• Your Runner’s High Is Similar to a Pot High (news-2015) http://www.thedailybeast.com/articles/2015/10/09/your-runner-s-high-is-similar-to-a-pot-high.html?ref=yfp
• 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. (Switzerland/ Austria, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490613/ 
• Endocannabinoids modulate human blood-brain barrier permeability in vitro. (UK, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459020/ 
• Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795159/ 
• Cannabidiol protects an in vitro model of the blood brain barrier (BBB) from oxygenglucose deprivation via PPARγ and 5-HT1A. (UK, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761095/ 
• Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficit. (Spain/ Germany, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454518/ 
• A Cannabinoid Receptor 2 Agonist Prevents Thrombin-Induced Blood-Brain Barrier Damage via the Inhibition of Microglial Activation and Matrix Metalloproteinase Expression in Rats. (China, link to PDF, 2015) https://www.researchgate.net/publication/282044189_A_Cannabinoid_Receptor_2_Agonist_Prevents_Thrombin-Induced_Blood-Brain_Barrier_Damage_via_the_Inhibition_of_Microglial_Activation_and_Matrix_Metalloproteinase_Expression_in_Rats