COCAINE and the ENDOCANNABINOID SYSTEM

COCAINE and the ENDOCANNABINOID SYSTEM:

• 2024
• Cannabidiol compared to pharmacological treatment as usual for crack use disorder: A feasibility, preliminary efficacy, parallel, double-blind, randomized clinical trial. https://link.springer.com/article/10.1007/s11469-024-01287-z? 
• Cannabidiol (CBD) facilitates cocaine extinction and ameliorates cocaine-induced changes to the gut microbiome in Male C57BL/6JArc Mice. https://www.sciencedirect.com/science/article/pii/S0278584624000824 
• 2020
• Cannabinoid Modulation of Food-Cocaine Choice in Male Rhesus Monkeys. (USA, link to PDF, 2020) https://jpet.aspetjournals.org/content/early/2020/01/15/jpet.119.263707.long 
• 2019
• Δ9-Tetrahydrocannabinol During Adolescence Attenuates Disruption of Dopamine Function Induced in Rats by Maternal Immune Activation. (Italy, full, 2019) https://www.frontiersin.org/articles/10.3389/fnbeh.2019.00202/full
• Marijuana, tobacco, alcohol and cocaine use during pregnancy in 2013 and 2016. A self-report study in Montevideo, Uruguay. (Uruguay, links to PDFs in English & Spanish, 2019) http://adicciones.es/index.php/adicciones/article/view/1107 
• Distinct inflammatory profiles in HIV-infected individuals under antiretroviral therapy using cannabis, cocaine or cannabis plus cocaine. (Brazil, abstract, 2019) https://pubmed.ncbi.nlm.nih.gov/31490211/ 
• Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-TH1A and TRPV1 receptor mechanisms. (USA, abstract, 2019) https://www.sciencedirect.com/science/article/abs/pii/S0028390819302990?via%3Dihub 
• 2018
• Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats. (USA/ Sweden/ Italy, full, 2018) https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30259-6
• Effects of Cocaine Self-Administration and Its Extinction on the Rat Brain Cannabinoid CB1 and CB2 Receptors. (Poland, full, 2018) https://link.springer.com/article/10.1007/s12640-018-9910-6 
• Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle. (USA/ Spain, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098033/ 
• Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. (USA/ Italy/ Sweden, full, 2018) https://www.nature.com/articles/s41598-018-31921-5 
• Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341999/ 
• Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus. (Spain, click the “holistichempextracts” link for download, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0028390818307135 
• Loren Parsons' contribution to addiction neurobiology. (Italy/ USA, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29949237/ 
• Opposing roles of type-1 and type-2 cannabinoid receptors in cocaine stimulant and rewarding effects. (Brazil/ Ireland, abstract, 2018) https://www.semanticscholar.org/paper/Opposing-roles-of-CB1-and-CB2-cannabinoid-receptors-Gobira-Oliveira/72069691b0ba5f96aa6c7d7c4cf2035231b44509 
• FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. (USA, abstract, 2018) https://www.semanticscholar.org/paper/FAAH-variant-Pro129Thr-modulates-subjective-effects-Patel-Nielsen/4deb30b50c0bb504c5efd28068b16af57392ae1d 
• 2017
• Marijuana Treatment And How Smoking Weed Can Help Ease The Crack Epidemic  (news–2017) https://www.ibtimes.com/marijuana-treatment-how-smoking-weed-can-help-ease-crack-epidemic-2541194
• Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice. (Spain, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486147/ 
• Psychostimulant Effect of the Synthetic Cannabinoid JWH-018 and AKB48: Behavioral, Neurochemical, and Dopamine Transporter Scan Imaging Studies in Mice. (Italy/ USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543288/ 
• The Epac-phospholipase Cε pathway regulates endocannabinoid signaling and cocaine-induced disinhibition of VTA dopamine neurons. (USA/ China, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354337/ 
• Post-sensitization treatment with rimonabant blocks the expression of cocaine-induced behavioral sensitization and c-Fos protein in mice. (Brazil, full, 2017) https://www.sciencedirect.com/science/article/pii/S0091305717301995?via%3Dihub 
• Intentional cannabis use to reduce crack cocaine use in a Canadian setting: A longitudinal analysis. (Canada, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500311/ 
• Demographic and clinical characteristics of treatment seeking women with full and sub-threshold PTSD and concurrent cannabis and cocaine use disorders. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575989/ 
• Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889367/ 
• Cannabis and cue-induced craving in cocaine-dependent individuals: A pilot study. (Canada, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0306460317301387 
• Epigenetic mechanisms associated with addiction-related behavioural effects of nicotine and/or cocaine: implication of the endocannabinoid system. (Japan, abstract, 2017) https://www.semanticscholar.org/paper/Epigenetic-mechanisms-associated-with-behavioural-Hayase/5d3d8dbbdffcb7c415a35ada77dd35fc624099e6 
• 17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors. (USA, abstract, 2017) https://pubmed.ncbi.nlm.nih.gov/28825421/    
• 2016
• Marijuana Vs. Cocaine Effects On The Brain: How Each Drug Alters Perception Of Time In Rats (news–2016) http://www.medicaldaily.com/marijuana-vs-cocaine-effects-brain-how-each-drug-alters-perception-time-rats-405828
• Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait. (Spain, full, 2016) https://www.hindawi.com/journals/np/2016/6481862/ 
• Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. (Taiwan/ Germany/ USA, full, 2016) https://www.nature.com/articles/ncomms12199 
• Attenuation of Cocaine-Induced Conditioned Place Preference and Motor Activity via Cannabinoid CB2 Receptor Agonism and CB1 Receptor Antagonism in Rats. (Greece/ USA, full, 2016) https://academic.oup.com/ijnp/article/20/3/269/2452654 
• Sleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845302/ 
• A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice. (USA/ Italy/ China, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118226/ 
• Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028287/ 
• Effects of an acute cannabidiol treatment on cocaine self-administration and cue-induced cocaine seeking in male rats. (Canada, full, 2016) https://journals.sagepub.com/doi/full/10.1177/0269881116667706 
• Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus. (Spain/ Argentina/ Germany, full, 2016) https://academic.oup.com/ijnp/article/18/1/pyu024/650989 
• Opposite regulation of cannabinoid CB1 and CB2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. (Spain, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S0304394016300192 
• Influence of thermal hair straightening on cannabis and cocaine content in hair. (Luxembourg, abstract, 2016) https://www.sciencedirect.com/science/article/pii/S0379073816000086 
• 2015
• Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913738/ 
• Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. (USA, full, 2015) https://www.cell.com/cell-reports/fulltext/S2211-1247%2815%2900926-2 
• CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703460/ 
• Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine. (Brazil, full, 2015) https://www.hindawi.com/journals/mi/2015/523418/ 
• Enhancement of endocannabinoid signalling protects against cocaine-induced neurotoxicity. (Brazil, full, 2015) https://www.sciencedirect.com/science/article/pii/S0041008X15001556 
• Addressing the stimulant treatment gap: A call to investigate the therapeutic benefits potential of cannabinoids for crack-cocaine use. (Canada/ Netherlands/ Brazil, full, 2015) https://www.sciencedirect.com/science/article/abs/pii/S095539591500300X 
• Species Differences in Cannabinoid Receptor 2 and Receptor Responses to Cocaine SelfAdministration in Mice and Rats. (USA/ China, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330519/ 
• Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release. (Brazil, abstract, 2015) https://www.sciencedirect.com/science/article/abs/pii/S0161813X15001229 
• 2011
• Cocaine, Opiate, and Cannabinoid Infant Mortality Study (news–2011) http://www.theweedstreetjournal.com/cocaine-opiate-cannabinoid-infant-mortality-study/
• Study: Marijuana compound helps mitigate cocaine addiction in mice (news–2011) http://www.rawstory.com/rs/2011/07/26/study-marijuana-compound-helps-mitigate-cocaine-addiction-in-mice/
• Can marijuana curb cocaine addiction? (news–2011) http://theweek.com/article/index/217709/can-marijuana-curb-cocaine-addiction