FRAGILE X SYNDROME

FRAGILE X SYNDROME:

According to Fragilex.org, "While it has long been known that individuals with Fragile X syndrome (FXS) often exhibit characteristics of autism spectrum disorder (ASD), only recently has the possibility been raised that the two conditions may have considerably more overlap than previously thought. Scientists at various Fragile X centers are studying whether this overlap may extend beyond mere behavioral similarities and perhaps include genetic or biological components as well."

See Library section on Autism

• 2020
• Can Cannabis Treat Autism (ASD) Symptoms? (news–2020)
  http://sensiseeds.com/en/blog/how-the-endocannabinoid-2-ag-may-reduce-symptoms-of-fragile-x-autism/
• 2019
• Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature. (USA, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446166/ 
• 2018
• Muscarinic M1 Receptor Modulation of Synaptic Plasticity in Nucleus Accumbens of Wild-Type and Fragile X Mice. (France/ USA, full, 2018) https://www.biorxiv.org/content/10.1101/270256v1.full
• Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's disease and Less Well-Known Diseases. (Spain, Abstract, 2018) https://www.ingentaconnect.com/content/ben/cmc/2019/00000026/00000018/art00009 
• 2017
• Cannabis CBD Treatments Approved For Fragile X Syndrome (news–2017)  https://cannabis.net/blog/medical/cannabis-cbd-treatments-approved-for-fragile-x-syndrome
• The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality? (France, full, 2017) https://www.frontiersin.org/articles/10.3389/fnsyn.2017.00015/full 
• Treating a novel plasticity defect rescues episodic memory in Fragile X model mice. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951717/ 
• 2016
• p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus. (Canada / China, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907698/ 
• Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model. (Spain, full, 2016) https://www.mdpi.com/2073-4425/7/9/56/htm 
• Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse. (France, full, 2016) https://academic.oup.com/cercor/article/27/12/5592/2333956 
• Dissecting the signaling pathways involved in the crosstalk between mGlu5 and CB1 receptors. (Brazil, PDF, 2016) https://molpharm.aspetjournals.org/content/early/2016/06/23/mol.116.104372.long 
• 2015
• Homer Protein-Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling and Affects Hyperexcitability in a Mouse Model of Fragile X Syndrome. (USA, full, 2015) https://www.jneurosci.org/content/35/9/3938.long 
• Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003021/ 
• Therapeutic approaches for the future treatment of Fragile X. (Spain, abstract, 2015) https://www.sciencedirect.com/science/article/pii/S2352154615000133 
• 2013
• New therapy for fragile X chromosome syndrome discovered (news–2013) https://www.sciencedaily.com/releases/2013/04/130410082413.htm
• Marijuana Affects Autism, But Not How You’d Think [Study] (news–2013) http://www.inquisitr.com/874575/marijuana-affects-autism-but-not-how-youd-think-study/
• 2012
• Marijuana cannabinoids found to help combat autism. (news – 2012)
  https://www.naturalnews.com/037445_marijuana_cannabinoids_autism.html
• 2011
• Boosting natural marijuana-like brain chemicals treats fragile X syndrome symptoms  (news–2011) https://www.sciencedaily.com/releases/2012/09/120925121349.htm