FRAGILE X SYNDROME – Leaf411

FRAGILE X SYNDROME:

According to Fragilex.org, "While it has long been known that individuals with Fragile X syndrome (FXS) often exhibit characteristics of autism spectrum disorder (ASD), only recently has the possibility been raised that the two conditions may have considerably more overlap than previously thought. Scientists at various Fragile X centers are studying whether this overlap may extend beyond mere behavioral similarities and perhaps include genetic or biological components as well."

See Library section on Autism

2024
Implication of the endocannabinoidome and metabolic pathways in Fragile X syndrome pathophysiology. https://pubmed.ncbi.nlm.nih.gov/38763080/
Cannabidiol and positive effects on object recognition in an in-vivo model of Fragile X syndrome: Obligatory role of hippocampal GPR55 receptors. https://www.sciencedirect.com/science/article/pii/S1043661824001208
2020
Can Cannabis Treat Autism (ASD) Symptoms? (news–2020)
http://sensiseeds.com/en/blog/how-the-endocannabinoid-2-ag-may-reduce-symptoms-of-fragile-x-autism/
2019
Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature. (USA, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446166/
2018
Muscarinic M1 Receptor Modulation of Synaptic Plasticity in Nucleus Accumbens of Wild-Type and Fragile X Mice. (France/ USA, full, 2018) https://www.biorxiv.org/content/10.1101/270256v1.full
Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's disease and Less Well-Known Diseases. (Spain, Abstract, 2018) https://www.ingentaconnect.com/content/ben/cmc/2019/00000026/00000018/art00009
2017
Cannabis CBD Treatments Approved For Fragile X Syndrome (news–2017) https://cannabis.net/blog/medical/cannabis-cbd-treatments-approved-for-fragile-x-syndrome
The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality? (France, full, 2017) https://www.frontiersin.org/articles/10.3389/fnsyn.2017.00015/full
Treating a novel plasticity defect rescues episodic memory in Fragile X model mice. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951717/
2016
p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus. (Canada / China, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907698/
Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model. (Spain, full, 2016) https://www.mdpi.com/2073-4425/7/9/56/htm
Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse. (France, full, 2016) https://academic.oup.com/cercor/article/27/12/5592/2333956
Dissecting the signaling pathways involved in the crosstalk between mGlu5 and CB1 receptors. (Brazil, PDF, 2016) https://molpharm.aspetjournals.org/content/early/2016/06/23/mol.116.104372.long
2015
Homer Protein-Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling and Affects Hyperexcitability in a Mouse Model of Fragile X Syndrome. (USA, full, 2015) https://www.jneurosci.org/content/35/9/3938.long
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. (USA, full, 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003021/
Therapeutic approaches for the future treatment of Fragile X. (Spain, abstract, 2015) https://www.sciencedirect.com/science/article/pii/S2352154615000133
2013
New therapy for fragile X chromosome syndrome discovered (news–2013) https://www.sciencedaily.com/releases/2013/04/130410082413.htm
Marijuana Affects Autism, But Not How You’d Think [Study] (news–2013) http://www.inquisitr.com/874575/marijuana-affects-autism-but-not-how-youd-think-study/
2012
Marijuana cannabinoids found to help combat autism. (news – 2012)
https://www.naturalnews.com/037445_marijuana_cannabinoids_autism.html
2011
Boosting natural marijuana-like brain chemicals treats fragile X syndrome symptoms (news–2011) https://www.sciencedaily.com/releases/2012/09/120925121349.htm