IMMUNE SYSTEM

IMMUNE SYSTEM:

• 2023
• ECS explained: Immune and Endocannabinoid systems. https://www.endocannabinoidmedicine.com/immune-and-endocannabinoid-systems/ 
• Cannabidiol on Innate Immunity: Experimental Evidence and Clinical Relevance. https://www.mdpi.com/1422-0067/24/4/3125 
• 2022
• Cannabinoids as Immune System Modulators: Cannabidiol Potential Therapeutic Approaches and Limitations. https://www.liebertpub.com/doi/abs/10.1089/can.2022.0133 
• 2020
• The Highs and Lows of Cannabis in Cancer Treatment and Bone Marrow Transplantation. (Israel, abstract, 2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000158/ 
• Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson's Disease. (USA/ Ireland, full, 2020) https://www.mdpi.com/1420-3049/25/3/453/htm 
• Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis. (Romania, full, 2020) https://www.mdpi.com/2073-4409/9/2/307/htm  
• 2019
• Self-reported Cannabis Use and Changes in Body Mass Index, CD4 T-Cell Counts, and HIV-1 RNA Suppression in Treated Persons with HIV. (USA, abstract, 2019) https://link.springer.com/article/10.1007%2Fs10461-019-02430-x 
• The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases. (Italy, full, 2019) https://www.mdpi.com/1422-0067/20/23/5875/htm 
• Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression. (Mexico, full, 2019) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220542 
• Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight. (Germany/ Russia, full, 2019) https://www.frontiersin.org/articles/10.3389/fphys.2019.00085/full 
• Sex differences in stress and immune responses during confinement in Antarctica. (Germany/ USA, full, 2019) https://bsd.biomedcentral.com/articles/10.1186/s13293-019-0231-0 
• Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation. (Israel, full, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387311/ 
• 2018
• Inflammation and CB2 signaling drive novel changes in the ocular lipidome and regulate immune cell activity in the eye. (Canada/ USA, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S109888231830025X?via%3Dihub 
• Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis. (Spain, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0006295218303630 
• Gene Expression of ABHD6, a Key Factor in the Endocannabinoid System, Can Be Modulated by Female Hormones in Human Immune Cells (Brazil, abstract, 2018) https://link.springer.com/article/10.1007%2Fs10528-018-9871-8 
• Cannabinoids for the treatment of rheumatic diseases - where do we stand? (Israel, abstract, 2018) https://www.nature.com/articles/s41584-018-0025-5 
• Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis. (USA, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29512125/ 
• 2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs. (Spain, abstract, 2018) https://pubmed.ncbi.nlm.nih.gov/29484707/ 
• Betacaryophyllene - A phytocannabinoid as potential therapeutic modality for human sepsis? (Mexico/ Canada, abstract, 2018) https://www.sciencedirect.com/science/article/abs/pii/S0306987717308617 
• The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus. (Iran, PDF, 2018) https://www.researchgate.net/publication/323296715_The_Role_of_Cannabinoid_Receptor_1_in_the_Immunopathology_of_Respiratory_Syncytial_Virus 
• Infectious risks associated with medicinal Cannabis: Potential implications for immunocompromised patients? (USA, PDF, 2018) https://www.researchgate.net/publication/322990000_Infectious_risks_associated_with_medicinal_Cannabis_Potential_implications_for_immunocompromised_patients 
• Endocannabinoid engagement of CB2 regulates RSV-induced immunity. (USA, full, 2018) https://www.tandfonline.com/doi/full/10.1080/21505594.2017.1421830 
• Interferon- α-mediated Activation of T Cells from Healthy and HIV-infected Individuals is Suppressed by Δ 9 –Tetrahydrocannabinol. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123667/ 
• Acute inflammation: endogenous cannabinoids mellow the harsh proinflammatory environment. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118573/ 
• HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γinducible protein 10 levels compared with nonusing HIV patients. (USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790621/ 
• A Fluorescent Probe to Unravel Functional Features of Cannabinoid Receptor CB1 in Human Blood and Tonsil Immune System Cells. (Spain/ Switzerland, full, 2018) https://pubs.acs.org/doi/10.1021/acs.bioconjchem.7b00680 
• Transcriptomic Characterization of the Human Habenula Highlights Drug Metabolism and the Neuroimmune System. (Canada/ USA, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220030/ 
• Cellular localization and regulation of receptors and enzymes of the endocannabinoid system in intestinal and systemic inflammation. (Austria, full, 2018) https://link.springer.com/article/10.1007/s00418-018-1719-0 
• An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. (Italy, full, 2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871676/ 
• Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus Infected Individuals. (USA, full, 2018) https://academic.oup.com/cid/article/66/12/1872/4869752 
• The current state and future perspectives of cannabinoids in cancer biology. (Poland, full, 2018) https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.1312 
• Vicious Circle Leads to Loss of Brain Cells in Old Age: THC May Help Reverse the Process (news/ abst – 2018) https://neurosciencenews.com/apoptosis-aging-9783/
• 2017
• Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: Evidence for defective immunomodulatory mechanisms. (Brazil/ Australia/ USA, abstract, 2017) https://www.sciencedirect.com/science/article/abs/pii/S0022395616307373 
• Participation of hypothalamic CB1 receptors in reproductive axis disruption during immune challenge. (Argentina, PDF, 2017) https://www.researchgate.net/publication/318081117_Participation_of_hypothalamic_CB1_receptors_in_reproductive_axis_disruption_during_immune_challenge 
• Effect of marijuana use on thyroid function and autoimmunity. (USA, PDF, 2017) https://www.researchgate.net/publication/309594708_Effect_of_Marijuana_Use_on_Thyroid_Function_and_Autoimmunity 
• Investigating the relationships between alcohol consumption, cannabis use and circulating cytokines: a preliminary analysis. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832595/ 
• Δ9-Tetrahydrocannabinol Suppresses Secretion of IFNα by Plasmacytoid Dendritic Cells From Healthy and HIV-Infected Individuals. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527743/ 
• Regulation of Cell Surface CB2 Receptor during Human B Cell Activation and Differentiation. (USA, full, 2017) https://escholarship.org/uc/item/8bw753bv#article_main 
• Effects of cannabinoid receptor type 2 in respiratory syncytial virus infection in human subjects and mice. (Iran/ Netherlands, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955186/ 
• A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784265/ 
• The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease. (Australia, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685274/ 
• Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges. (Hungary, full, 2017) https://www.frontiersin.org/articles/10.3389/fimmu.2017.01487/full 
• Immunoregulatory Role of Cannabinoids during Infectious Disease. (Mexico, full, 2017) https://www.karger.com/Article/FullText/481824  
• Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation. (UK/ Iraq, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674070/ 
• Parameters of the Endocannabinoid System as Novel Biomarkers in Sepsis and Septic Shock. (Canada, full, 2017) https://www.mdpi.com/2218-1989/7/4/55/htm 
• Interactions between gut microbes and host cells control gut barrier and metabolism. (Belgium, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485881/ 
• Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology? (Poland, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337874/ 
• Role of Endocannabinoids on Neuroinflammation in Autism Spectrum Disorder Prevention. (Saudi Arabia, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535348/ 
• Endocannabinod Signal Dysregulation in Autism Spectrum Disorders: A Correlation Link between Inflammatory State and Neuro-Immune Alterations. (Italy/ USA, full, 2017) https://www.mdpi.com/1422-0067/18/7/1425/htm 
• Endocannabinoid system acts as a regulator of immune homeostasis in the gut. (USA, full, 2017) https://www.pnas.org/content/early/2017/04/18/1612177114.long 
• Innate lymphoid cells in asthma: cannabinoids on the balance. (Switzerland, full, 2017) https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.13145
• Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice. (USA, full, 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314369/ 
• Chili peppers, marijuana may reduce gut inflammation (news–2017) http://www.medicalnewstoday.com/articles/317128.php
• Marijuana may help HIV patients keep mental stamina longer (news – 2017)
  https://www.eurekalert.org/pub_releases/2017-12/msu-mmh121217.php
• 2016
• Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. (Italy, abstract, 2016) https://www.jni-journal.com/article/S0165-5728(16)30274-0/fulltext 
• Medical Cannabis - another piece in the mosaic of autoimmunity? (Israel, abstract, 2016) https://pubmed.ncbi.nlm.nih.gov/27859024/ 
• Modulation of monocytes by bioactive lipid anandamide in multiple sclerosis involves distinct Toll-like receptors. (Italy/ UK, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S1043661816309021 
• Experimental Cannabinoid 2 Receptor Inhibition in CNS Injury-Induced Immunodeficiency Syndrome. (Canada, abstract, 2016) https://www.semanticscholar.org/paper/Experimental-Cannabinoid-2-Receptor-Inhibition-in-Burkovskiy-Zhou/d6e60966df88b038624ee9de3d383ff2d52fc770 
• Microglia activation states and cannabinoid system: Therapeutic implications. (Spain, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S0163725816301012 
• Reduced Noradrenergic Signaling in the Spleen Capsule in the Absence of CB1 and CB2 Cannabinoid Receptors. (USA, abstract, 2016) https://www.semanticscholar.org/paper/Reduced-Noradrenergic-Signaling-in-the-Spleen-in-of-Simkins-Fried/47fa42837d2ac1fe289ae19a2f984c2d1f553b1e 
• Toll-like receptor signalling as a cannabinoid target in Multiple Sclerosis. (Ireland, abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S0028390816301459 
• The emerging role of the cannabinoid receptor family in peripheral and neuro-immune interactions. (Ireland, abstract, 2016) https://www.eurekaselect.com/138448/article 
• Cannabinoids and autoimmune diseases: A systematic review. (Israel, Abstract, 2016) https://www.sciencedirect.com/science/article/abs/pii/S1568997216300349 
• Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response. (Italy, PDF, 2016) https://www.researchgate.net/publication/304361367_Cannabinoids_and_Neuro-Inflammation_Regulation_of_Brain_Immune_Response 
• Cannabidiol (CBD) induces functional Tregs in response to low-level T cell activation. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327652/ 
• Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers. (Poland/ Sweden, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812478/  
• Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154806/  
• CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418123/ 
• Anandamide Suppresses Proinflammatory T Cell Responses In Vitro through Type-1 Cannabinoid Receptor-Mediated mTOR Inhibition in Human Keratinocytes. (Italy/ France, full, 2016) https://www.jimmunol.org/content/197/9/3545.long 
• Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed type hypersensitivity. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206973/ 
• Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. (USA/ Taiwan/ Hungary/ Switzerland/ Israel, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004721/ 
• The CB2 receptor and its role as a regulator of inflammation. (Canada, full, 2016) https://link.springer.com/article/10.1007/s00018-016-2300-4 
• CB2 and GPR55 Receptors as Therapeutic Targets for Systemic Immune Dysregulation. (Canada, full, 2016) https://www.frontiersin.org/articles/10.3389/fphar.2016.00264/full 
• Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. (Israel/ USA, full, 2016) https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0603-x 
• Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2. (China, full, 2016) https://www.oncotarget.com/article/7042/ 
• 3D Structure of Protein That Guides the Immune System Uncovered (news & abst–2016) http://neurosciencenews.com/trpv2-ion-channel-immune-system-3448/
• Study Reveals Role of Spleen in Prolonged Anxiety After Stress (news–2016) http://neurosciencenews.com/stress-anxiety-spleen-5507/
• 2015
• Can marijuana help transplant patients? New research says maybe (news–2015) http://www.eurekalert.org/pub_releases/2015-09/foas-cmh090115.php
• 2014
• Cannabidiol (CBD) May Increase Lung Cancer’s Susceptibility To Specialized Killer Cells (news–2014) https://www.medicaljane.com/2014/08/28/study-cannabinoids-may-increase-lung-cancers-susceptibilty-to-specialized-killer-cells/
• 2013
• Targeting the Endocannabinoid System to Treat Sepsis (review–2013) http://www.signavitae.com/2013/05/targeting-the-endocannabinoid-system-to-treat-sepsis/
• 2012
• Novel compounds to activate cannabinoid receptors in immune system wins award for young Hebrew University researcher (news–2012) http://www.huji.ac.il/cgi-bin/dovrut/dovrut_search_eng.pl?mesge133966745705872560