LONG TERM and HEAVY USE EFFECTS

LONG TERM and HEAVY USE EFFECTS:

• 2024

• Bidirectional Effect of Long-term Delta-9-Tetrahydrocannabinol treatment on mTOR activity and Metabolome. https://pubs.acs.org/doi/10.1021/acsptsci.4c00002 

  • What this article reports is; that in a mouse model, long-term delta-9-THC "first increases the level of energy and synaptic protein production in the brain, followed by a reduction in mTOR activity and metabolic processes in the periphery. Our study suggests that a dual effect on mTOR activity and the metabolome could be the basis for an effective antiaging and pro-cognitive medication."

• Impact of year-long cannabis use for medical symptoms on brain activation during cognitive processes. https://pubmed.ncbi.nlm.nih.gov/38746368/ 
• Limited Psychological and social effects of lifetime cannabis use frequency: Evidence from a 30-year community study of 4,078 twins. https://pubmed.ncbi.nlm.nih.gov/38147055/ 
• 2023
• Cannabis use and Incident Atrial Fibrillation in a longitudinal cohort.  https://www.heartrhythmjournal.com/article/S1547-5271(23)03058-8/fulltext#%20 
• A descriptive analysis of adverse event reports from the Quebec Cannabis Registry. https://pubmed.ncbi.nlm.nih.gov/37996777/ 
• Distress tolerance and problematic cannabis use: does the form of cannabis matter? https://pubmed.ncbi.nlm.nih.gov/37565482/
• A large Australian longitudinal cohort registry demonstrates sustained safety and efficacy of oral medicinal cannabis for at least two years. https://pubmed.ncbi.nlm.nih.gov/36399463/
• Cannabis Use Disorder:  https://www.ncbi.nlm.nih.gov/books/NBK538131/    
• Associations between state-level policy liberalism, cannabis use, and cannabis use disorder from 2004 to 2012: Looking beyond medical cannabis law status:  https://www.sciencedirect.com/science/article/abs/pii/S095539591830272X
• Gene linked to cannabis abuse:  https://www.sciencedaily.com/releases/2019/06/190618104828.htm
• Here’s What Researchers Know So Far About How Marijuana Legalization Affects Public Health: https://www.marijuanamoment.net/heres-what-researchers-know-so-far-about-how-marijuana-legalization-affects-public-health/
• 2018
• Urgent need for federal investment in research on cannabis health impacts, say  researchers (article–2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798990/
• Legalization Doesn’t Increase Problematic Marijuana Use, Study Finds. (news – 2018)
  https://www.marijuanamoment.net/legalization-doesnt-increase-problematic-marijuana-use-study-finds/
• 2017
• Marijuana researcher hopes legalization will open door to more study (news–2017) http://ipolitics.ca/2017/04/08/marijuana-researcher-hopes-legalization-will-open-door-to-more-study/
• Cannabis Connection: Does Weed Make You Dumb? (news–2017) https://www.pastemagazine.com/articles/2017/05/does-cannabis-make-you-dumb.html
• Regular marijuana users have more sex, study says. (news – 2017)
  https://www.cnn.com/2017/10/27/health/marijuana-increased-sex/index.html
• Medicinal cannabis: Doctors, nurses and Nimbin ‘elders’ trade marijuana tips.
  (news – 2017) https://www.abc.net.au/news/2017-06-23/medicinal-cannabis-drug-melbourne-course-caldicott/8643204
• 2016
• Minimal Physical Health Risk Associated With Long-term Cannabis Use—But Buyer Beware. (USA, full, 2016) https://moffittcaspi.trinity.duke.edu/sites/moffittcaspi.trinity.duke.edu/files/cannabis-health-comment_0.pdf 
• Environmental cues and attempts to change in daily cannabis users: An intensive longitudinal study. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792644/ 
• Association Between Regular Cannabis Use and Ganglion Cell Dysfunction. (France, full, 2016) https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2589167 
• Hippocampal harms, protection and recovery following regular cannabis use. (Australia, full, 2016) https://www.nature.com/articles/tp2015201 
• Comparing adults who use cannabis medically with those who use recreationally: Results from a national sample. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915997/ 
• Grey Matter Changes Associated with Heavy Cannabis Use: A Longitudinal sMRI Study (Netherlands, full, 2016) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152482 
• fMRI study of neural sensitization to hedonic stimuli in long-term, daily cannabis users. (USA, full, 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012952/ 
• Associations Between Cannabis Use and Physical Health Problems in Early Midlife. (USA/ New Zealand/ UK, full, 2016) https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2526003 
• Association Between Lifetime Marijuana Use and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. (USA/ Switzerland, full, 2016) https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2484906 
• Marijuana – How Safe is it Really? (article-link to PDF–2016) https://journals.mcmaster.ca/iScientist/article/download/1104/991
• Study says long-term pot use causes poor gum health – but not much else (news–2016) http://www.theguardian.com/society/2016/jun/01/long-term-pot-use-study-poor-gum-health-marijuana
• Marijuana Use Linked to Increased Gum Disease Risk (news–2016) https://www.perio.org/consumer/marijuana-use
• Largest ever longitudinal twin study of adolescent cannabis use finds no relationship heavy use and IQ decline (news–2016) http://thescienceexplorer.com/brain-and-body/largest-ever-twin-study-finds-no-link-between-smoking-pot-and-iq-decline
• More Proof That Marijuana Keeps You Thin, Fit And Active (news–2016) https://thefreshtoast.com/cannabis/more-proof-that-weed-keeps-you-thin/#sthash.2OdtF6Je.dpuf
• More people are smoking weed every day, ‘like cigarettes’, study reveals (news–2016) http://metro.co.uk/2016/08/15/more-people-are-smoking-weed-every-day-like-cigarettes-study-reveals-6068652/
• 2015
• Daily pot use not associated with brain shrinkage: Colorado study (news–2015) http://news.yahoo.com/daily-pot-not-associated-brain-shrinkage-colorado-study-235549441.html
• What It’s Like To Smoke Pot Every Day For 50 Years (news–2015)  https://www.yahoo.com/health/what-its-like-to-smoke-pot-every-day-for-50-years-117780070001.html
• No sign of safety risks with longterm pot use for chronic pain (news–2015) http://arstechnica.com/science/2015/09/no-sign-of-safety-risks-with-long-term-pot-use-for-chronic-pain/
• Teen marijuana use not linked to later depression, lung cancer, other health problems,  study finds (news–2015)  http://www.sciencedaily.com/releases/2015/08/150804093718.htm
• One in every 17 college students smokes marijuana on daily or near-daily basis (news–2015) http://www.news-medical.net/news/20150901/One-in-every-17-college-students-smokes-marijuana-on-daily-or-near-daily-basis.aspx
• 2014
• Marijuana Use Results in Less Domestic Violence (news–2014) http://blog.sfgate.com/smellthetruth/2014/08/19/marijuana-in-marriage-equals-less-violence-study-finds/
• 2013
• Chronic cannabis abuse, delta-9-tetrahydrocannabinol and thyroid function (letter-2013) https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0032-1316342
• Long-Term Cannabis Use Is Associated With Better Health Than Long-Term Tobacco use (news-2013) http://hempedification.blogspot.com/2013_04_01_archive.html
• Marijuana habit not linked to lung cancer (news-2013) http://www.thctotalhealthcare.com/marijuana-habit-not-linked-to-lung-cancer-oncology-practice-reports/
• Marijuana has no adverse effects on health, BU study suggests (news-2013) http://dailyfreepress.com/2013/09/25/marijuana-has-no-adverse-effects-on-health-bu-study-suggests/
• No detectable association between frequency of marijuana use and health or healthcare utilization (news-2013) http://medicalxpress.com/news/2013-09-association-frequency-marijuana-health-healthcare.html
• 2012
• Pot smoking not tied to middle-age mental decline (news-2012) http://www.reuters.com/article/2012/01/04/us-drugs-idUSTRE8030AE20120104
• One Joint a Week for 49 Years Doesn’t Harm Lungs, Research Finds (news-2012) http://www.smh.com.au/world/science/one-joint-a-week-for-49-years-doesnt-harm-lungs-research-finds-20120111-1puhg.html
• 2011
• 125 Year Old Woman Claimed Smoking Cannabis Everyday Was Her Secret to Long Life (news–2011) http://www.hanf-info.ch/info/en/125-Year-Old-Woman-Claimed-Smoking.html
• Cannabis use and Cognitive function: 8-year trajectory in a young adult cohort. https://pubmed.ncbi.nlm.nih.gov/21749524/